Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Importance of Peer Review in Toxicological Pathology and Its Practical Approach

독성병리 Peer Review의 중요성과 실제적 접근방법

  • 손우찬 ;
  • 김배환 ((주)태평양 기술연구원 전임상연구센타) ;
  • 장동덕 (국립독성연구원 독성연구부) ;
  • 한범석 (국립독성연구원 독성연구부) ;
  • 양기화 (국립독성연구원 독성연구부) ;
  • 이영순 (서울대학교 수의과대학 수의공증보건학교실)
  • Published : 2004.03.01
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Abstract

Evaluation of toxicological pathology is to some extend subjective judgments by pathologist and the accuracy of pathologist's works is based on the individual training and experiences. It has been required to establish a peer review system for toxicologic pathology and these review system has been employed by various practice of toxicological pathology. It would be pointed out that the possible causes of drifts in pathology are due to 1) lack of knowledge or experience of individual pathologists, 2) poorly maintained consistence of grading among animals in study, 3) different interpretation of findings between pathologists, or 4) pathology data processing. Example cases of diagnostic errors and current practice of peer review including tissue selection criteria, documentation and problem resolution for short-term and carcinogenicity studies were introduced. For sound regulatory system and high integrity of practice in toxicological pathology, current approaches of peer review system were reviewed.

Keywords

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