YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Involvement of $\alpha_2$-Receptor in Extremely Low Frequency Magnetic Field-induced Hyperalgesia in Mice

극저주파 자기장으로 유도한 생쥐의 통각과민에 $\alpha_2$-수용체의 관련성

  • 정지훈 (중앙대학교 약학대학 약물학실) ;
  • 박해자 (중앙대학교 약학대학 약물학실) ;
  • 김정수 (중앙대학교 약학대학 약물학실) ;
  • 송현주 (중앙대학교 약학대학 약물학실) ;
  • 손의동 (중앙대학교 약학대학 약물학실)
  • Published : 2004.10.01
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Abstract

The purpose of this study is to prove how magnetic field (MF) acts on sympathetic neuro-transmissions using thermal response. Mice were divided into two groups and each one was exposed to MF (20 G, 24 hrs) or sham. Every vehicle or drugs were treated a half hour before the thermal response test. The pain threshold was lowered by MF (20 G, 24 hrs) alone. This reduction of pain threshold by MF was not blocked by a single treatment of $\alpha$-receptor antagonist (prazosin), $\alpha$$_2$-receptor agonist (clonidine, guanabenz), $\beta$$_1$-receptor antagonist (atenolol) or $\beta$$_1$,$\beta$$_2$-receptor antagonist (propranolol). But administration of $\alpha$$_2$-receptor antagonist (yohimbine) completely inhibited the decrease in pain threshold by MF. Moreover, it increased by high dose of yohimbine over normal condition. These results suggest that MF acts on sympathetic nerve terminal to induce hyperalgesia, in which pre-synaptic az receptor might be involved.

Keywords

References

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