약학회지 (YAKHAK HOEJI)

  • 제48권5호
  • /
  • Pages.272-277
  • /
  • 2004
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

치오우레이도 MAPP 유도체의 합성과 세포독성

Synthesis and Cytotoxlcity of Thioureido MAPP Derivatives

  • 전상철 (중앙대학교 약학대학 ·의약화학 교실) ;
  • 김연숙 (중앙대학교 약학대학 ·의약화학 교실) ;
  • 김미영 (중앙대학교 약학대학 ·의약화학 교실) ;
  • 임채욱 (중앙대학교 약학대학 ·의약화학 교실) ;
  • 임철부 (중앙대학교 약학대학 ·의약화학 교실)
  • 발행 : 2004.10.01
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초록

The 2-amino-l-phenylpropanols 4∼7 were reacted with isothiocyanates to afford the 20 thioureido MAPP derivatives 8a∼11e, which were tested their cytotoxic activity by MTT assay. The cytotoxicity of alkylthioureido compounds were increased and decreased by alkyl chain length from $C_{8}$ to $C_{14}$ and of phenylthioureido compounds showed poor activity. The compounds (8b, 8c, 9b, 9c, l0b, 10c, 11b, 11c) with $C_{10}$ and $C_{12}$ alkyl chains gave stronger activity than reference compound B13. The $IC_{50}$/ of compound 8c was 1.05$\mu$M and 3 times stronger activity than B13. The stereochemistry of synthesized compounds affected very little to cytotoxic activity.

키워드

참고문헌

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