YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of the Cultivated Fruit body of Phellinus linteus on Low Density Lipoprotein Oxidation

배양상황버섯의 저밀도지질단백질 (LDL)산화에 미치는 영향

  • 정은주 (숙명여자대학교 약학대학) ;
  • 성재모 (강원대학교 농업생명과학대학) ;
  • 양기숙 (숙명여자대학교 약학대학)
  • Published : 2004.04.01
Download PDF
⟨ Previous Next ⟩

Abstract

Phellinus linteus (Hymenocaetaceae) has been used for the treatment of gastric cancer, noninsulin dependant diabetes, diarrhea, and menstrual irregularity. The antioxidative effect of cultivated fruit body of Phellinus linteus on low density lipoprotein oxidation was investigated. The MeOH and water extracts were examined by TEARS assay on human plasma LDL in vitro system. The MeOH ex. showed antioxidative activity, and then was fractionated into Precipitates, Water Insoluble fr., Water fro and ether fro The results showed that the lipophilic fractions, Water Insoluble fr. and Ether fr. of cu 1-tivated fruit body of Phellinus linteus, inhibited the oxidative modification of LDL.

Keywords

References

  1. 박완희, 이호득 : 한국약용버섯도감, 교학사, 서울 p. 504 (1999)
  2. Ying, J., Mao, X., Ma, Q., Zong, Y. and Wen, H. : leones of medicinal fungi from China, Science Press. Beijing. China.182 (1987)
  3. Tsuneo, N : The encyclopedia of Wakan-Yaku (II), Hoikusa, Japan 244 (1995)
  4. 정경수, 김신숙, 김희수, 한만우, 김병각 : Phellinus linteus 균사 배양물로 부터 분리한 단백다당체 Kp 항암활성. 약학회지 38, 158 (1994)
  5. Lee, J. H., Cho, S. M., Song, K. S., Hong, N. D. and Yoo, I. D. : Characterization of carbohydrate-peptide linkage of acidic heteroglycopeptide with immuno-stimulating activity from mycelium of Phellinus linteus. Cherm Pharm. Bull, 44, 1093 (1996)
  6. Song, K. S., Cho, S. M., Ko, K. S., Han, M. W. and Yoo, I. D. : Secondary metabolites from the mycelial culture broth of Phellinus linteus. Kor. J. Agric. Cherm. & Biotechnol. 37, 100 (1994)
  7. 김창수 : 목질진흙버섯 (phellinus linteus)의 성분분석. 충북대학교 석사 학위논문 (1997)
  8. 三橋 博 : 原色收野和漢藥草大圖鑑, 北隆館 700 (1988)
  9. Ikegawa, T., Nakanishi, M., Uehara, N., Chihara, G. and Fukuoka, F. : Antitumor action of some Basidiomycetes, Espesially Phellinus linteus. Gann 59, 155 (1968)
  10. Chung, K. S., Kim, S. S., Kim, H. S., Kim, K. Y., Han, M. W. and Kim, K. H. : Effect of Kp, an antitumor protein-polysaccharide from mycelial culture of Phellinus Iinteus on the humoral immune response of tumor-bearing ICR mice to sheep red blood cell. Arch. Pharm. Res. 16, 336 (1993) https://doi.org/10.1007/BF02977527
  11. Oh, G. T，Han, S. B., Kim, H. M., Han, M. W. and Yoo, I. D. : Immuno-stimuIating activity of Phellinus linteus extracts to Blymphocyte. Arch. Pharm. Res. 15, 379 (1992) https://doi.org/10.1007/BF02974118
  12. Song, K. S., Cho, S. M., Lee, J. H., Kim, H. M., Han, S. B., Ko, K. S. and Yoo, I. D. : B-lymphocyte-stimuIating polysaccharide from mushroom Phellinus linteus. Chem. Pharm. Bull. 43, 2105 (1995). https://doi.org/10.1248/cpb.43.2105
  13. Song, C. H., Ra, K. S. Yang, B. K. and Jeon, Y. J. : Immunostimulating activity of Phellinus linteus. Kor. J. Mycol. 26, 86 (1998)
  14. 한용석, 박순영, 최병기, 정세영 : 재배 상황버섯 추출물의 경구 투여 급성 독성 연구. 응용약물학회지 9, 46 (2001)
  15. Park, Y. J., Yang, K. S., Kim, T. H. and Kim, T. W. : Effect of glucose and nonenzymatic glycation on LDL oxidation. Kor. J. Lipidology 5, 249 (1995)
  16. Fukujawa, K. and Takaishi, Y. : Antioxidants. J. Act. Oxyg. Free Rad. 1, 55 (1990)
  17. 皆川信子 : 活性酸素か關與する代表的疾患. フアルマシア　29, 1029 (1993)
  18. Ginter, E. : A new concept of atherogenesis : the role of oxygen radicals. Vnitr. Lek. 38, 1096 (1992)
  19. Aviram, M. : Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radic. Res. 33, 85 (2000)
  20. Inkeda, T. and Fukuzuma, K. : Tocopherol as antioxidants I oxidation of methyl linolate. J. Japan oil Chem. Soc. 26, 343 (1977)
  21. Converse, C. A. and Skinmer, E. R. : Lipoprotein analysis, A Practical approach, Oxford University, New York, 113 (1992)
  22. Lowry, O. H., Rosebrough, N. J.. Farr, A. L. and Randall, R. J. : Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265 (1951)
  23. Choi, J. H., Park，Y. J., Son, H. S., Yang, K. S. and Kim T. W.: Functional properties of modified low density lipoprotein and degradation of modified LDL by human monocyte macrophages. J. Kor. Soc. Food Nutr. 24, 362 (1995)
  24. 정해영 : Free radical에 의한 노화 및 발암기전. 한국노화학회지 2, 1 (1992)
  25. Halliwell, B. : Drug antioxidant effects, A basis for drug selection. Drugs 42, 569 (1991) https://doi.org/10.2165/00003495-199142040-00003
  26. Aviram, M. : Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radic. Res. 33, 85 (2000)
  27. Iede, N., Nelson, A. B. and Lau, B. H. : Aged garlic extract and its constituentss inhibit Cu$2^+$-induced oxidative modification of low density lipoprotein. Planta Medica 63, 263 (1997) https://doi.org/10.1055/s-2006-957668
  28. Chen, G. C., Hardman, D. A., Hamilton, R. L., Mendel，C. M. ，Schilling, J. W., Zhu, S., Lau, K., Wong, J. S. and Kane, J. P. : Distribution of lipid binding rgions in human apolipoprotein B-100. J. Biochem. 28, 2477 (1989) https://doi.org/10.1021/bi00432a019
  29. Choi, J. H., Son, H. S. and Kim, T. W. : Fatty acid composition and functional properties of low density lipoprotein and oxidized LDL from human plasma. J. Kor. Soc. Food Nutr. 23, 402 (1994)
  30. Yan, L. J., Droy-Lefaix, M. T. and Packer, L. : Ginkgo biloba extract (EGb 761) protects human low density lipoproteins against oxidative modification mediated by copper. Biochem. Biophy. Res. Commun. 212 , 360 (1995) https://doi.org/10.1006/bbrc.1995.1978
  31. Kim, J. H. and Yang, K. S. : Antilipid peroxidative effect of Houtturynia cordata 45, 494 (2001)
  32. Kim, E. J. and Yang, K. S. : Effect of Astragali Radix on low density lipoprotein Oxidation 45, 529 (2001)
  33. Steinbrecher, U. P. : Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products. J. Biol. Chem. 262, 3603 (1987)
  34. 박종옥, 김경순, 지영애, 류병호 : 갈근에서 분리한 daidzin 및 puerarin 의 사람low density lipoprotein에 대한 항산화효과. 한국식품영양과학회지 26, 25 (1997)