Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Micronization of Ibuprofen by Cryogenic Ball Milling

극저온 볼 밀링을 통한 Ibuprofen 분말의 마이크로화

  • Published : 2004.11.01
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Abstract

For the present study, the cryogenic ball milling process was applied to make Ibuprofen microsized. The cryogenic ball milling was performed at low temperature of about -18$0^{\circ}C$ for 6 hours. The particle size distribution was determined before and after the cryogenic process. X-ray diffraction (XRD) measurement was made to determine the effect of cryogenic process on the crystallinity of Ibuprofen. The results showed that the size of Ibuproffn was reduced about 10 times by the cryogenic process. The degree of crystallinity of Ibuproffn was slightly reduced by the cryogenic process.

Keywords

References

  1. Brabander, C. D., Vervaet, C, Bortel, L. V. and Remon., J. P., 'Bioavailability of ibuprofen from hot-melt extruded mini-matrices,' Int. J. of Pharmaceutics, Vol. 271, pp. 77-84, 2004 https://doi.org/10.1016/j.ijpharm.2003.10.029
  2. Rasenack, N. and MGller, B. W., 'Ibuorofencrystals with optimized properties,' Int. J. of Pharmaceutics, Vol, 245, pp. 9-24., 2002 https://doi.org/10.1016/S0378-5173(02)00294-6
  3. Kayarak, D., Akman, U. and Hortacu, O., 'Micronization of Ibuprofen by RESS,' J. of Supercritical Fluids, Vol. 26, pp. 17-31., 2003 https://doi.org/10.1016/S0896-8446(02)00248-6
  4. http://www.wyeth.com
  5. Zhou, F., Liao, X.Z., Zhu, Y. T., Dallek, S. and Lavernia, E. J., 'Microstructural evolution during recovery and recrystallization of a nanocrystalline Al-Mg alloy prepared by cryogenic ball milling,' Acta Materialia, Vol. 51, pp. 2777-2791, 2003 https://doi.org/10.1016/S1359-6454(03)00083-1
  6. Huang, B., Perez, R. J., Crawford, P. J., Sharif, A.A., Nutt, S. R. and Lavernia, E. J., 'Mechanically induced crystallization of metglas $Fe_{78}B_{13}Si_9$ during cryogenic high energy ball milling,' NanoStructured Materials, Vol. 5, pp. 545-553, 1995 https://doi.org/10.1016/0965-9773(95)00261-C
  7. Schilling, P. J., He, J. H., Tittsworth, R. C. and Ma, E., 'Two-Phase coexistence region in mechanically alloyed Cu-Fe: an X-Ray absortion near-edge structure study,' Acta mater, Vol. 47, pp. 2525-2537, 1999 https://doi.org/10.1016/S1359-6454(99)00111-1
  8. Kim, Y. M., Jeung, J. M., Lee, S. J. and Kim, Y. J., 'TEM Specimen Preparation Method of Gibbsite Powder for Quantitative Structure Analysis,' Korean J. Electron Microscopy, Vol.32, No. 4, pp. 311-317, 2002
  9. Uchida, R., 'X - ray Diffraction Analysis,' Ban-Do Publishing Company, pp. 256-258, 1991
  10. Nam, T. H. and Kang, S. H., 'Effect of Milling Conditions on the Microstructure and the Transformation Behavior of Ti-Ni AND Ti-Ni-Cu Shape Memory Alloy Powders,' METALS AND MATERIALS Int, Vol. 8, No. 2, pp. 145-150, 2002 https://doi.org/10.1007/BF03027010