YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Near-infrared Spectroscopic Measurement of Glucose Under the Existence of Other Major Blood Components

혈액의 주요 구성물질 존재 하에서 근적외분광분석법을 이용한 글루코오스 측정

  • 백주현 (동덕여자대학교 약학대학) ;
  • 강나루 (동덕여자대학교 약학대) ;
  • 우영아 (동덕여자대학교 약학대) ;
  • 김효진 (동덕여자대학교 약학대학)
  • Published : 2004.06.01
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Abstract

This study was described for measuring clinically relevant levels of glucose in undiluted plasma and whole blood by near-infrared (NIR) spectroscopy. Result from an initial measurement of major blood components powder was over-lapped the absorption bands of glucose at 1500-1600 nm. However, the NIR data of blood components were clearly separated by principle component analysis (PCA) space. By the use of partial least squares (PLS) regression, glucose concentrations in undiluted plasma and whole blood could be determined with standard errors of prediction (SEP) of 15 mg/dl and 76 mg/dl, respectively. Although these blood components possessed strong absorption bands that overlapped with the absorption bands of glucose, successful calibration models could be carried out.

Keywords

References

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