Biotechnology and Bioprocess Engineering:BBE

  • 제9권3호
  • /
  • Pages.191-195
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  • 2004
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  • 1226-8372(pISSN)
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  • 1976-3816(eISSN)
한국생물공학회 (The Korean Society for Biotechnology and Bioengineering)
권호 표지

Pectin Microspheres for Oral Colon Delivery: Preparation Using Spray Drying Method and In Vitro Release of Release of Indomethacin

  • Lee, Chang-Moon (Interdisciplinary Program of Biomedical Engineering, Chonnam National University) ;
  • Kim, Dong-Woon (Department of Health and Hygiene, Gwang-Yang Health College) ;
  • Lee, Hyun-Chul (Department of Microbiology, Chonnam National University Medical School) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering and The Research Institute for Catalysis, Chonnam National University)
  • 발행 : 2004.06.01
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초록

Drug delivery systems that are based on pectin have been studied for colon specific delivery using the specific activity of colon microflora. The aim of this study was to design a novel method of manufacturing pectin microspheres without oils and surfactants and to investigate the potential use of the pectin microspheres as an oral colon-specific drug carrier. The pectin microspheres were successfully formed using the spray drying method and crosslinking with calcium chloride. From the crosslinked pectin microspheres, indomethacin (IND) release was more suppressed than its release from non-crosslinked microspheres. In a low pH (pH 1.4) environment, the pectin microspheres released IND at an amount of about 18${\pm}$2% of the total loaded weight for 24 h while the release rate of IND was stimulated at neutral pH (pH 7.4). IND release from the pectin microspheres was increased by the addition of pectinase. The results clearly demonstrate that the pectin microspheres that were prepared by the spray drying and crosslinking methods are potential carriers for colon-specific drug deliveries.

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참고문헌

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