Effects of Fermented Liquid of Males meles with Medicinal Plants on the Menopausal Symptoms, Estradiol Content and Bone Health Indices in the Postmenopausal Women

한약재를 첨가한 오소리 발효액이 폐경기 증후군과 Estradiol 농도 및 골대사에 미치는 영향

  • 박성혜 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 한종현 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 김윤홍 (㈜삼주) ;
  • 이윤희 (부천대학 식품영양과)
  • Published : 2004.06.01

Abstract

The purpose of this study was to investigated the possibility of Meles meles as an edible functional resource. To assess the effects of Meles meles fermented liquid(ML) with medicinal plants in postmenopausal women, the menopause symptoms, hematological and serum chemical variables and bone health indices were examined. Twenty five postmenopausal women participated in the study. As a result, in postmenopausal women, ML supplements were effective in reducing the incidence of menopause symptoms, such as insomnia(44.0%), sensitivity(40.0%), headache(34.0%), hot flush and decreased vaginal lubrication(20.0%) after 12 weeks. Also serum estradiol and calcitonin and calcium levels were 23.27 pg/mL, 14.88 pg/mL and 8.86 mg/dL before the ML intake. Levels were significantly increased of estradiol and calcitonin and calcium after ML intake during 12 weeks to 30.36 pg/mL, 21.61 pg/mL and 10.01 mg/dL. Osteocalcin and bone alkaline phosphatase activity were 14.36 ng/mL, 21.55 U/L before the ML intake, but according to ML intake, the levels were significantly decreased. In conclusion, ML play benefical roles in the prevention of bone loss and menopause symptoms. Howere current data are not sufficient to determine the effective doses for benefical effect as well as harmful effect and support dietary recommendation level for ML. Therefore, our results should be viewed with caution. But Meles meles fermented liquid with medicinal plants can be used as possible food resources and functional food materials, more studies are needed to identify the proper mechanism of ML.

Keywords

References

  1. 한의학사전 김현제;홍윤식
  2. 생화학적 분석의 의의 녹십자의료재단
  3. 임상병리검사법 이세열;정윤섭
  4. 식·약용 오소리 사육전서 이희춘;한석록
  5. 중약대사전 중앙대사전 편찬위원회
  6. 식품공전 한국식품공업협회
  7. 방약합편 황도연
  8. MS Thesis. Yonsei University Dose-response relationships of isoflavone on menopausal symptoms, lipid profiles, total antioxidant status, bone alkaline phosphatase activity in perimenopausal and postmenopausal women Choi,Y.
  9. J Korean Socity of Menopause v.2 Composition of biochemical markers of bone tumover in postmenopausal women Chung,H.Y.;Lim,C.H.;Kim,S.W.;Han,K.O.;Han,I.K.;Min,H.K.
  10. Hypolipidemic effects of dietary omega-3 fatty acids in normal and hyperlipidemic humans Connor,W.E.
  11. Nutr Rev v.44 Linolenate-derived polyunsaturated fatty acid and prevention of atherosclerosis Dyerberg,J.
  12. Orthopedic Clin North Am v.21 Nutrition and bone Einhom,T.A.;Levine,B.;Michel,P.C.
  13. Science v.241 Evidence of estrogen receptors in normal human osteoblast-like cells Eriksen,E.F.
  14. J Strudies Alcohol v.45 Effects of alcohol on the endocrine function in postmenopausal women Gavaler,J.S.
  15. Clinical Chemistry v.3 Prevention of age related bone loss Gordon,G.S.;Vaugham,C.
  16. Osteoporo Int v.1 Potential risk factors for development of postmenopausal osteoporosis-examed over a 12-years period hansen,M.A.;Overgard,K.;Riis,B.J.;Christiansen,C.
  17. Am J Clin Nutr v.50 Nutritional factors in bone health in eldely subjects Heaney,R.P.
  18. Clin Endorinol v.31 no.4 Sex hormone binding glubulin in postmenopausal women Herment,A.M.;Birkenhager,J.C.;De Jong F.H.;Vandenbroucke,J.P.;Valkenburg,H.A.
  19. Alternatine & Complementary Therapies v.4 Phytoestrogens for a healthier menopause Holt,S.
  20. PH. D. Dissertation. Chungnam National University Effects of alcohol drinking on bone mineral density and serum estradiol level in postmenopausal women Kim,E.S.
  21. Korean J Menopause v.4 Effect of progesterone on bone mineral density and lipid metabolism in the hormone replacement therapy of the postmenopausal women Kim,S.H.;Park,K.Y.
  22. 식품의약품안전청고시 제2003-33 Korean Food & Drug Association
  23. Metabolism v.42 Is alcohol and osteoporosis-inducing agent for young and middle-aged women Laitinen,K.;Karkkainen,M.;Lalla,M.
  24. Korean J Nutrition v.25 Effects of nutrient intake on bone mineral density in postmenopausal women Lee,B.Y.;Chang,Y.K.;Choi,K.S.
  25. Korean J Menopause v.1 Effects of conjugated estrogen on bone mineral metabolism in postmenopausal women Lee,J.Y.;Choi,Y.M.;Lee,K.S.;Lee,S.G.;Kim,S.H.;Shin,C.J.;Kim,J.G.;Moon,S.Y.;Chang,Y.S.
  26. J Korean Bone Metabolism v.1 Application and diagnosis of bone tumover marker Lim,S.K.
  27. Lancet v.1 Long term prevention of postmenopausal osteoporosis by estrogens Lindsay,R.;Hart,D.M.;Aitken,J.M.
  28. Mythologies of menopause in Japan and North America Lock,M.
  29. Obstet Gynecol v.26 Loss of compact bone due to menopause Meena,H.E.;Bunker,M.C.;Meena,S.
  30. N England J Med v.328 Association of hormone-replacement therapy with various cardiovascular risk factors in postmenopausal women Nabulsi,A.A.;Folsom,A.R.;White,A.
  31. Clinical Obstetric and Gynecology v.41 The symptoms of perimenopause Nachtigall,L.E.
  32. Am J Obstet Gynecol v.161 Estrogen replacement therapy indications, contraindications an agent selection Notelovitz
  33. Korean J Food Cookery Sci v.20 Study on the Meles meles as applications in edible food resource Park,S.H.;Park,S.J.;Kim,K.Y.;Han,J.H.
  34. MS Thesis. Yonsei University The effects of isoflavone supplementation on bone metabolism in ovariectomized SD rats Park,Y.H.
  35. Am J Med v.94 Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis Peck,W.A.;Burckhardt,P.;Christiansen,C.
  36. Arch Intern Med v.53 A review of the association of estrogen and progestins with cardiovascular disease in postmenopausal women Psaty,B.M.;Heckbert,S.R.;Atkins,D.
  37. New Engl J Med v.37 Relative contributions of aging and estrogen deficiency to postmenopausal bone loss Richelson,L.S.;Wahner,H.W.;Melton,L.J.
  38. Alcohol v.25 Alcohol and bone disease Rico,H.
  39. N Engl J Med v.314 Involutional osteoporosis Riggs,B.L.;Melton,L.J.
  40. N England J Med v.280 Estrogens in menopause and postmenopause Rogers,J.
  41. N Engl J Med v.322 Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia Seed,M.;Hoppichler,F.;Reaveley,D.
  42. Am J Clin Nutr v.54 Omega-3 fatty acids in health and disease and in growth and development Simopoulos,A.P.
  43. Prostaglandins Leukotrienes Med v.15 Defective desaturation and elongation of n-6 and n-3 acids in hypertensive patients Singer,P.;Jaeger,W.;Viogt,S.
  44. Lipids in human nutrition Spiller,G.A.
  45. Hormones and aging Timiras,P.S.;Quary,W.D.;Vernadakis,A.
  46. Alcohol v.1 Sex hormones and adrenocortical steroid in men acutely intoxicated with ethanol Valimaki,M.J.;Harkonen,M.;Eriksson,C.J.P.
  47. J Clin Endocrinol Metab v.85 Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women Wangen,K.E.;Duncan,A.M.
  48. World Rev Nutr Diet v.66 Cardiovascular effects of ω3 fatty acids Weber,P.C.;Leaf,A.
  49. Lancet v.335 Apolipoprotein(a) and ischaemic heart disease in familial hypercholesterolaemia Wiklund,O.;Angelin,B.;Olofsson,S.O.
  50. Proc Soc Exp Biol Med v.186 Declining adrenal androgens Wild,R.A.;Buchanan,J.R.;Myers,C.