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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis and Biological Evaluation of New Thiazolopyrimidines

  • Makarem-Said (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University) ;
  • Khaled-Abouzid (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain-Shams University) ;
  • Ashraf-Mouneer (Department of Organic Chemistry, Faculty of Pharmacy, Cairo University) ;
  • Ali-Ahmedy (Department of Microbiology, Faculty of Pharmacy, Cairo University) ;
  • Osman, Abdel-Moneim (Pharmacology Unit, NCI, Cairo University)
  • Published : 2004.05.01
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Abstract

In this study, a series of 4-amino-5-cyano-3-substituted-2,3-dihydrothiazol-2-thiones (1a-c), as well as their triazolo and triazinopyrimidine derivatives such as 8-substituted-3-benzyl-5-meth-ylthiazolo[5,4-e][1,2,4] triazolo[1,5-c]pyrimidin-2-thiones (4-6, 10) and 3-benzyl-5-methyl thiazolo[5,4-e]pyrimidino[3,4-b][1,2,4]triazin-2-thiones (7a-b) were prepared as potential antimicrobial and antitumor agents. Some of the tested compounds showed promising antimicrobial activity and non of them showed any appreciable antitumor activity.

Keywords

References

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