Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In Vivo Antitumor Activity of Hydrophilic Arginine-Conjugated Linoleic Acid Complex

  • Kim, Young-Jun (Department of Food and Biotechnology, Korea University) ;
  • Lee, Ki-Won (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Dae-Ok (Department of Food Science and Technology, Cornell University) ;
  • Kim, Tae-Wan (Department of Animal Science, Cornell University) ;
  • Lee, Seong-Kweon (Lipozen Inc.) ;
  • Lee, Hyong-Joo (Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University)
  • Published : 2004.04.01
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Abstract

Although conjugated linoleic acid (CLA) exerted potent antitumor activities in several animal models, application of CLA as a bioactive ingredient has been limited due to its hydrophobicity. This study was designed to determine the antitumor activity of arginine-CLA complex (Arg-CLA), a hydrophilic form of CLA. Mouse forestomach cancer was induced by gavage with benzo(a)pyrene (B(a)p) for 4-weeks prior to Arg-CLA (0.2 and 0.5％) feeding. Complete necropsies were performed to determine the number, size and locations of all the forestomach tumors at 20 weeks post-B(a)P administration. All mice in the B(a)P group developed tumors, and tumor incidences were decreased by 31 ％ and 44％ in 0.2％ and 0.5％ Arg-CLA-fed groups, respectively, whereas no decrease was observed when Arg or com oil was given alone. Our results suggest that Arg-CLA suppresses mouse forestomach cancer.

Keywords

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