Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
권호 표지

Inhibitory Effect of Clavicepitaceae on Serotonin Release out of Human Platelets and Human Platelet Aggregation

  • Cho, Hyun-Jeong (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
  • Ham, Hye-Seon (Cancer Research Institute, Seoul National University, College of Medicine Yeongeon-dong) ;
  • Lim, Chang-Ryul (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
  • Park, Sun-A (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
  • Kang, Hyo-Chan (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
  • Ju, Young-Cheol (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University) ;
  • Park, Hwa-Jin (Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University)
  • Published : 2004.03.01
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Abstract

We have investigated the effects of hypha-water extracts (HWE), fruit body-water extracts (FWE) and cordycepin from Cordyceps militaris on serotonin release out of human platelets and human platelet aggregation. HWE and FWE inhibited the release of [$^3H$]-serotonin from human platelet stimulated by thrombin (2 U/ml) or collagen (20$\mu$g/ml) in a dose-dependent manner. Furthermore, cordycepin, a major component of Cordyceps militaris, inhibited the human platelet aggregation induced by collagen (10$\mu$g/ml) in a dose-dependent manner. These results suggest that cordycepin containing in HWE and FWE may inhibit the serotonin release by suppressing the collagen-induced human platelet aggregation. Accordingly, our data demonstrate that HWE and FWE containing much cordycepin might have antithrombotic and antimigrainous functions.

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