References
- Bai, C. X., Sunami, A., Namiki, T., Sawanobori, T., and Furukawa, T., Electrophysiological effects of ginseng and ginsenoside Re in guinea pig ventricular myocytes. Eur. J. Pharmacol., 476,35-44 (2003) https://doi.org/10.1016/S0014-2999(03)02174-5
- Chang, L. and Karin, M., Mammalian MAP kinase signalling cascades. Nature, 410, 37-40(2001) https://doi.org/10.1038/35065000
- Choi, S., Jung, S. Y., Ko, Y. S., Koh, S. R., Rhim, H., and Nah, S. Y., Functional expression of a novel ginsenoside Rf binding protein from rat brain mRNA in Xenopus laevis oocytes. Mol. Pharmacal., 61,928-935 (2002) https://doi.org/10.1124/mol.61.4.928
-
Fei, X. F., Wang, B. X., Tashiro, S., Li, T. J., Ma, J. S., and Ikejima, T., Apoptotic effects of ginsenoside
$Rh_2$ on human malignant melanoma A375-S2 cells. Acta Pharmacol. Sin., 23,315-322 (2002) - Hommes, D. W., Peppelenbosch, M. P., and van Deventer, S. J., Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut, 52, 144-151 (2003) https://doi.org/10.1136/gut.52.1.144
- Hooks, S. B., Santos, W. L., Im, D. S., Heise, C. E., Macdonald, T. L., and Lynch, K. R., Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J. Biol. Chem., 276, 4611-4621 (2001) https://doi.org/10.1074/jbc.M007782200
- Im, D. S., Heise, C. E., Harding, M. A., George, S. R., O'Dowd, B. F., Theodorescu, D., and Lynch, K. R., Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Mol. Pharmacol., 57, 753-759 (2000)
-
Kim, N. D., Kang, S. Y., Kim, M. J., Park, J. H., and SchiniKerth, V. B., The ginsenoside
$Rg_3$ evokes endotheliumindependent relaxation in rat aortic rings: role of$K^+$ channels. Eur. J. Pharmacol., 367, 51-57(1999) https://doi.org/10.1016/S0014-2999(98)00899-1 -
Kim, N. D., Kang, S. Y, Park, J. H., and Schini-Kerth, V. B., Ginsenoside Rg3 mediates endathelium-dependent relaxation in response to ginsenosides in rat aorta: role of
$K^+$ channels. Eur. J. Pharmacol., 367,41-49 (1999) https://doi.org/10.1016/S0014-2999(98)00898-X -
Kim,Y. S., Kim, D. S., and Kim, S. I., Ginsenoside
$Rh_2$ and$Rh_3$ induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside$Rh_2$ . Int. J. Biochem. Cell Biol., 30, 327-338 (1998) https://doi.org/10.1016/S1357-2725(97)00141-6 -
Kim, Y. S., Jin, S. H., Lee, Y. H., Park, J. D., and Kim, S. I., Differential expression of protein kinase C subtypes during ginsenoside
$Rh_2$ -Induced apoptosis in SK-N-BE(2) and C6Bu-1 cells. Arch. Pharm. Res., 23, 518-524 (2000) https://doi.org/10.1007/BF02976583 -
Lee, S. R., Park, J. H., Choi, K. J., and Kim, N. D., Inhibitory effects of ginsenoside
$Rh_3$ on platelet aggregation and its mechanism of action. Kor. J. Ginseng Sci., 21, 132-140 (1997) - Lee, Y. N., Lee, H. Y., Chung, H. Y., Kim, S. I., Lee, S. K., Park, B. C., and Kim, K. W., In vitro induction of differentiation by ginsenoides in F9 teratocarcinoma cells. Eur. J. Cancer, 32A, 1420-1428 (1996)
-
Liao, B., Newmark, H., and Zhou, R., Neuroprotective effects of ginseng total saponin and ginsenosides
$Rb_1$ and$Rg_1$ on spinal cord neurons in vitro. Exp. Neurol., 173, 224-234 (2002) https://doi.org/10.1006/exnr.2001.7841 - Liu, W. K., Xu, S. X., and Che, C. T., Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci., 67,1297-1306 (2000) https://doi.org/10.1016/S0024-3205(00)00720-7
-
Nah, S. Y., Park, H. J., and McCleskey, E. W., A trace component of ginseng that inhibits
$Ca^{2+}$ channels through a pertussis toxin-sensitive G protein. Proc. Natl. Acad. Sci. U. S. A., 92, 8739-8743 (1995) https://doi.org/10.1073/pnas.92.19.8739 -
Nakata, H., Kikuchi, Y., Tode, T., Hirata, J., Kita, T., Ishii, K., Kudoh, K., Nagata, I., and Shinomiya, N., Inhibitory effects of ginsenoside
$Rh_2$ on tumor growth in nude mice bearing human ovarian cancer cells. Jpn. J. Cancer Res., 89, 733-740 (1998) https://doi.org/10.1111/j.1349-7006.1998.tb03278.x - Odashima, S., Ohta, T, Kohno, H., Matsuda, T., Kitagawa, I., Abe, H., and Arichi, S., Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. Cancer Res., 45, 2781-2784 (1985)
-
Oh, M., Choi, Y. H., Choi, S., Chung, H., Kim, K., Kim, S. I., Kim, D. K., and Kim, N. D., Anti-proliferating effects of ginsenoside
$Rh_2$ on MCF-7 human breast cancer cells. Int. J. Oncol., 14, 869-875 (1999) - Ohta, H., Sato, K., Murata, N., Damirin, A., Malchinkhuu, E., Kon, J., Kimura, T., Tobo, M., Yamazaki, Y., Watanabe, T., Yagi, M., Sato, M., Suzuki, R., Murooka, H., Sakai, T., Nishitoba. T.. lm. D. S.. Nochi. H.. Tamoto. K.. Tomura. H.. and Okajima, F., Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors. Mol. Pharmacol., 64, 994-1005 (2003) https://doi.org/10.1124/mol.64.4.994
-
Park, J. A., Lee, K. Y., Oh, Y. J., Kim, K. W., and Lee, S. K., Activation of caspase-3 protease via a Bcl-2-insensitive pathway during the process of ginsenoside
$Rh_2$ -induced apoptosis. Cancer Lett., 121, 73-81 (1997) https://doi.org/10.1016/S0304-3835(97)00333-9 - Putney, J., W., Jr. and Bird, G. S., The inositol phosphatecalcium signaling system in nonexcitable cells. Endocr. Rev., 14,610-631 (1993) https://doi.org/10.1210/edrv-14-5-610
-
Rhim, H., Kim, H., Lee, D. Y, Oh, T. H., and Nah, S. Y., Ginseng and ginsenoside
$Rg_3$ , a newly identified active ingredient of ginseng, modulate$Ca^{2+}$ channel currents in rat sensory neurons. Eur. J. Pharmacol., 436, 151-158 (2002) https://doi.org/10.1016/S0014-2999(01)01613-2 - Rhim, J. S. and Kung, H. F., Human prostate carcinogenesis. Crit. Rev. Oncog., 8, 305-328 (1997) https://doi.org/10.1615/CritRevOncog.v8.i4.20
- Sandler, H. M., Narayan, S., and Smith, D. C., Combined modality treatment for prostate cancer: role of chemotherapy. Semin. Oncol., 30, 95-100 (2003) https://doi.org/10.1016/S0093-7754(03)00274-4
- See, W. A., Adjuvant hormone therapy after radiation or surgery for localized or locally advanced prostate cancer. Curr. Treat. Options Oncol., 4, 351-362 (2003) https://doi.org/10.1007/s11864-003-0036-5
- Teicher, B. A., Kakeji, Y., Ara, G., Herbst, R. S., and Northey, D., Prostate carcinoma response to cytotoxic therapy: in vivo resistance. In vivo, 11, 453-461 (1997)
- Theyer, G., Schirmbock, M., Thalhammer, T., Sherwood, E. R., Baumgartner, G., and Hamilton, G., Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines. J. Urol., 150, 1544-1547 (1993) https://doi.org/10.1016/S0022-5347(17)35838-X
- Wasllenko, W. J., Cooper, J., Palad, A. J., Somers, K. D., Blackmore, P. F., Rhim, J. S., Wright, G. L., Jr., and Schellhammer, P. F., Calcium signaling in prostate cancer cells: evidence for multiple receptors and enhanced sensitivity to bombesin/GRP. Prostate, 30,167-173 (1997) https://doi.org/10.1002/(SICI)1097-0045(19970215)30:3<167::AID-PROS4>3.0.CO;2-J
- Yun, T. K., Lee, Y. S., Lee, Y. H., Kim, S. I., and Yun, H. Y., Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. J. Kor. Med. Sci., 16 Suppl, S6-18 (2001) https://doi.org/10.3346/jkms.2001.16.S.S6