Abstract
The process for the preparation of fungicide propineb starting with 1,2-diaminopropane was studied on the optimal condition base. Side reaction producing toxic material 1,2-propylenethiourea could be ieduced effectively by using phase transfer catalyst and the product was noticed to show a great improvement in yield and purity. Especially when the phase transfer catalyst tetraphenylphosphonium bromide is used, the yield and the purity of the product were found to be best with up to 95 and 96% respectively and the byproduct content was shown within 1.7%. Also, the contents of wetting agent AES and dispersing agent APS were optimally chosen $3.1\sim4.0%$ and $4.0%\sim5.0%$ respectively for the improvement of suspensibility and wettability of Propineb WP.
1,2-Diaminopropane을 출발물질로 하는 원예용 살균제 propineb의 제조공정을 최적화하였다. 독성 부 반응물인 1,2-propylenethiourea의 발생을 억제하기 위하여 상전이 촉매를 사용하였으며, 이때 product의 수율과 순도가 획기적으로 향상됨을 확인하였다. phosphonium 염계 상전이 촉매인 tetraphenylphosphonium bromide를 사용한 경우 생성물의 순도 96%, 수율 95% 및 부반응물 함량 1.7%로 가장 좋은 결과를 보였다. 또한 propineb의 현수성과 수화성을 개선하기 위하여 AES를 수화성 계면활성제로, APS를 현수성 계면활성제로 사용하였으며, 이들의 최적 조건은 AES $3.1\sim4.0%$, APS $4.0\sim5.0%$이었다.
