Asian-Australasian Journal of Animal Sciences

  • 제17권3호
  • /
  • Pages.366-370
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  • 2004
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Effects of Florfenicol and Chromium (III) on Humoral Immune Response in Chicks

  • Cao, Jiyue (Laboratory of Pharmacology and Physiology, College of Veterinary Medicine, Huazhong Agricultural University) ;
  • Li, Kui (Laboratory of Molecular Biology & Animal Breeding, College of Animal Science and Technology, Huazhong Agricultural University) ;
  • Lu, Xiaocong (Wuhan Institute of Botany, The Chinese Academy of Sciences) ;
  • Zhao, Yaxin (Laboratory of Pharmacology and Physiology, College of Veterinary Medicine, Huazhong Agricultural University)
  • 투고 : 2002.11.20
  • 심사 : 2003.10.11
  • 발행 : 2004.03.01
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초록

One hundred and sixty day-old Hainan chicks were randomly allotted into eight pens to investigate the effect of different dietary concentrations of chromium (Cr) in the form of chromium chloride, and different dosages of florfenicol on humoral immune responses by determining antibody titers to Newcastle disease (ND) vaccines using the hemagglutination inhibition test. The results indicated that ND antibody titers were significantly higher in chicks receiving Cr at low (5 mg/kg feed) and middle (10 mg/kg feed) dose compared with the control (p<0.01). However, ND antibody titers were significantly decreased in chicks receiving Cr at a high dosage of 500 mg/kg feed (p<0.01), though the ND antibody titers of the early days (d 21 and d 28 of age) were higher than that of the control group. It is suggested that excessive Cr intake has detrimental effects on ND antibody production in chicks. No significantly lower response was measured in chicks that received florfenicol at a low dosage of 50 mg/kg feed (p>0.05), but the ND antibody titers were significantly decreased in chicks receiving 200 and 400 mg/kg feed of the drug (p<0.01). The ND antibody titers of group receiving 200 mg/kg feed of florfenicol plus 10 mg/kg Cr were slightly higher than that of the group receiving single florfenicol of 200 mg/kg although, no significant differences were observed between these two treatments. It is suggested that the humoral immune response impaired by florfenicol (200 mg/kg feed) could not be significantly reversed by Cr (10 mg/kg feed).

키워드

참고문헌

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피인용 문헌

  1. Effects of florfenicol on the immune responses and the interferon-inducible genes in broiler chickens under the impact of E. coli infection vol.38, pp.1, 2014, https://doi.org/10.1007/s11259-013-9585-7
  2. The influence of enrofloxacin, florfenicol, ceftiofur and E. coli LPS interaction on T and B cells subset in chicks vol.39, pp.1, 2015, https://doi.org/10.1007/s11259-015-9632-7
  3. Dietary chromium supplementation for heat-stressed broilers vol.74, pp.01, 2018, https://doi.org/10.1017/S0043933917001064
  4. Effects of supplemental chromium on interferon-gamma (IFN-γ) mRNA expression in response to Newcastle disease vaccine in broiler chicken vol.85, pp.1, 2008, https://doi.org/10.1016/j.rvsc.2007.08.003
  5. Effects of Oral Administration of CrCl3 on the Contents of Ca, Mg, Mn, Fe, Cu, and Zn in the Liver, Kidney, and Heart of Chicken vol.171, pp.2, 2016, https://doi.org/10.1007/s12011-015-0559-1
  6. Effects of Excess Cr3+ on Trace Element Contents in the Brain and Serum in Chicken vol.177, pp.1, 2017, https://doi.org/10.1007/s12011-016-0875-0