Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지

Expression of osteopontin in developing mouse brain

발달 중인 생쥐 뇌에서의 Osteopontin 발현

  • Kim, Gyubeom (Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University) ;
  • Hwang, Insun (Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University) ;
  • Mun, Changjong (Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University) ;
  • Shin, Taekyun (Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University) ;
  • Son, Hwa-young (College of Veterinary Medicine, Chungnam National University) ;
  • Jee, Youngheun (Department of Veterinary Medicine, College of Agriculture and Life Science, Cheju National University)
  • 김규범 (제주대학교 농업생명과학대학 수의학과) ;
  • 황인선 (제주대학교 농업생명과학대학 수의학과) ;
  • 문창종 (제주대학교 농업생명과학대학 수의학과) ;
  • 신태균 (제주대학교 농업생명과학대학 수의학과) ;
  • 손화영 (충남대학교 수의과대학) ;
  • 지영흔 (제주대학교 농업생명과학대학 수의학과)
  • Accepted : 2004.08.09
  • Published : 2004.09.30
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Abstract

This study was undertaken to examine the developmental expression of osteopontin(OPN) in the mouse brain. In Western blotting analysis, the expression of OPN was noted initially at embryonic stage and increased gradually after birth and decreased at postnatal day 60(P60). In immunohistochemistry, OPN expression was found in the interstitial nucleus Cajal and the substantia nigra reticularis in anterior part of the brain and in the inferior olivary complex, the parabrachial nucleus, the facial nucleus, the gigantocellular reticular nucleus, the trigeminal nucleus and the anterior interposed nucleus in posterior part of the brain at P31 and P60. In addition, OPN expression in widespread neurons appeared during the period of neuronal differentiation, increased just after birth and decreased with maturation. These results suggest that OPN contributes to developmental processes, including the differentiation and maturation of specific neuronal populations.

Keywords

References

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