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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Structure-based Functional Discovery of Proteins: Structural Proteomics

  • Jung, Jin-Won (Department of Biochemistry and Protein Network Research Center, College of Science, Yonsei University) ;
  • Lee, Weon-Tae (Department of Biochemistry and Protein Network Research Center, College of Science, Yonsei University)
  • Published : 2004.01.31
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Abstract

The discovery of biochemical and cellular functions of unannotated gene products begins with a database search of proteins with structure/sequence homologues based on known genes. Very recently, a number of frontier groups in structural biology proposed a new paradigm to predict biological functions of an unknown protein on the basis of its three-dimensional structure on a genomic scale. Structural proteomics (genomics), a research area for structure-based functional discovery, aims to complete the protein-folding universe of all gene products in a cell. It would lead us to a complete understanding of a living organism from protein structure. Two major complementary experimental techniques, X-ray crystallography and NMR spectroscopy, combined with recently developed high throughput methods have played a central role in structural proteomics research; however, an integration of these methodologies together with comparative modeling and electron microscopy would speed up the goal for completing a full dictionary of protein folding space in the near future.

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References

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