${\beta}-Endorphin$의 내피세포의존성-세로토닌 유도-근 수축 억제와 저빈도-주파수 은침점전자극의 혈장 ${\beta}-endorphin$ 증가

Inhibition of Endothelial Cell-dependent Serotonin-induced Contraction of ${\beta}-endorphin$ and Increment of Plasma ${\beta}-endorphin$ of Silver Spike Point Low Frequency Electrical Stimulation

The purpose of this study was to demonstrate the effects of silver spike point (SSP) low frequency electrical stimulation on plasma ${\beta}-endorphin$ activities measured by radio- immunoassay from normal volunteer and the effects of ${\beta}-endorphin$ on 5-hydroxytryptamine (5-HT, serotonin)-induced contraction investigated by isometric tension methode in rats. The current of 3 Hz continue type, but not 100 Hz continue type, of SSP low frequency electrical stimulation significantly increased in plasma ${\beta}-endorphin$ from normal volunteer. The endothelial cell-dependent 5-HT-induced contractions were inhibited by ${\beta}-endorphin$ $1{\mu}M$. These results suggest that the ${\beta}-endorphin$ regulates nociceptive-like substance, such as 5-HT, in part and that the SSP low frequency electrical stimulation, specifically current of low frequency of 3 Hz continue type, significantly increases plasma ${\beta}-endorphin$ from normal volunteer.