대한치과교정학회지 (The korean journal of orthodontics)

  • 제34권6호
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  • Pages.526-536
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  • 2004
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  • 2234-7518(pISSN)
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  • 2005-372X(eISSN)
대한치과교정학회 (The Korean Association Of Orthodontists)
권호 표지

급속상악확대술 시행 후 지대치와 지지골 표면에 나타나는 치근흡수의 불화나트륨 단독투여를 통한 예방에 대하여

The effect of NaF on bone and tooth resorption around an anchor tooth during a rapid maxillary expansion procedure

  • 발행 : 2004.12.01
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초록

본 연구는 급속상악확대술 시행 후 보정기간중에 지대치의 압박측 치근흡수에 불화나트륨의 경구 투여가 영향을 미치는지를 알아보기 위하여 시행되었다. 이차성징을 아직 나타내지 않은 10마리 소아기 암캐에 견치를 주지대치로 사용하는 주조형 상악 확대장치를 제작, 장착하였다 상악확대장치는 20일간에 걸쳐 5mm 확장시켰으며, 교합면 방사선사진을 이용하여 정중구개봉합의 이개를 확인하였다. 실험동물은 실험군 5 마리와 대조군 5 마리로 나뉘었으며, 보정기간 중 실험군에는 2.2 mg/kg/day의 불화나트륨 (불소로서 1.0mg/kg/day)을 캅셀제의 형태로 1 일 2 회로 나누어 단독 경구 투여하였다. 실험동물들을 보정 후 0 일, 15 일, 30 일, 45 일, 및 60 일째에 각 군당 한 마리씩 배정하여 충분한 마취로 희생시킨 후 상악골을 절취하였다. 이후 실험동물의 좌측 상악 견치의 압박측 치근표면과 압박측 견치 협면을 덮고 있던 골 조직의 치아측 표면을 주사전자현미경을 이용하여 관찰하였다. 본 실험에서 압박측 치근표면을 관찰한 결과 45일 보정군과 60일 보정군의 대조군에서 흡수소와가 발현되는 빈도가 높았다. 지대치 압박측 치근을 덮는 골면에 나타나는 흡수소와의 발현은 30일의 보정기간 이후부터 실험군에서 적게 나타남을 알 수 있었다. 차후 급속상악확대술을 시행하는 경우 효과적인 NaF의 투여시기와 용량에 대한 검증이 필요하리라 생각된다.

This study was undertaken to determine the effect of a 2.2mg/Kg/day intraoral administration of NaF on the amount of root resorption and osteoclastic activity during or after a rapid maxillary expansion procedure. Ten puerile female dogs were divided into two groups: a control group and a NaF-treated group. A fixed type maxillary expansion device was delivered to all dogs. The appliance was activated twice daily throughout a 20-day period, causing a 5-mm expansion of maxillary bone. After the expansion procedure, the animals were sacrificed at days 0, 15, 30, 45, and 60 of the retention period. The buccal surface of the root of each maxillary canine was examined by means of a surface electron microscope (SEM). Using SEM, web-like resorption lacunae were observed on the bone or the tooth surface at the site of osteoclastic activity; these observations were verified by histological methods. No peculiar resorption lacunae were found in the apical tip of the roots of either the control group or the NaF-treated group animals. The NaF-treated retention group was found to have less resorption lacunae formation on day 45 and day 60. The preventative effect of NaF on resorption lacunae formation on the surface of the bone covering the anchor tooth was confirmed. Larger areas of resorption lacunae were found on the surface of the bone covering the canines in the control group animals, as compared to those of the NaF-treated group, especially on day 30 and day 60. Using SEM, the present study revealed a difference between the control group and the NaF-treated group in the prevalence and the size of the resorption lacunae formation on the cemental root surface. The preventative effect of NaF on bone resorption was confirmed. Further studies concerned with the optimum concentration of NaF that has an effect in vivo are necessary.

키워드

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