Korean Journal of Clinical Pharmacy (한국임상약학회지)
- Volume 14 Issue 1
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- Pages.32-35
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- 2004
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- 1226-6051(pISSN)
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- 2508-786X(eISSN)
Pharmacokinetics of Verapamil in Rabbits with Hepatic Disorder Induced by Carbon Tetrachloride
간장장애 가토에서 베라파밀의 약물동태
- Choi, Jun-Shik (College of Pharmacy, Chosun University) ;
- Kim, Hyung-Jung (Korean Food and Drug Administration)
- Published : 2004.06.01
Abstract
The purpose of this study was to investigate the pharmacokinetic changes of verapamil in rabbits with hepatic disorder induced by carbon tetrachloride. The plasma concentrations of verapamil were increased significantly (p<0.05, in slight group; P<0.01, in moderate and severe group) in all groups of hepatic disorder compared to the control group. Morover, the