Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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Effects of Kangwhal-Sokdantang Extract on Osteoblast Function

강활속단탕(羌活續斷湯)이 골세포(骨細胞) 기능(機能)에 미치는 영향(影響)

  • Lee Taek-Jun (Dept. of Oriental Medicine, Graduate School, Wonkwang University) ;
  • Hong Ji-Woo (Dept. of Oriental Medicine, Graduate School, Wonkwang University) ;
  • Choi Hyun-Ju (Dept. of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Gil In-Ho (Dept. of Oriental Medicine, Graduate School, Wonkwang University) ;
  • Jeong Sun-Chung (Dept. of Oriental Medicine, Graduate School, Wonkwang University) ;
  • Hwang Gui-Seo (Dept. of Oriental Medicine, Kyungwon University) ;
  • Lee Ki-Nam (Dept. of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 이택준 (원광대학교 대학원 한의학과) ;
  • 홍지우 (원광대학교 대학원 한의학과) ;
  • 최현주 (원광대학교 한의학전문대학원 제3의학과) ;
  • 길인호 (원광대학교 대학원 한의학과) ;
  • 정선충 (원광대학교 대학원 한의학과) ;
  • 황귀서 (경원대학교 한의학과) ;
  • 이기남 (원광대학교 한의학전문대학원 제3의학과)
  • Published : 2004.12.29
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Abstract

This study was performed to evaluate the effect of Kangwhal-Sokdan tang(KS) on osteoblast function and gene expression. The osteoblast separated from the murine calvariae and MG-63 cell were cultivated to evaluate the cell function and gene expression. The results were summarized as followes. 1) KS increased cell proliferation of murine calvarial cell. 2) KS increased protein synthesis, collagen synthesis and ALP activity of murine calvarial cell. 3) KS increased the survival rate of murine calvarial cell. 4) KS increased the expression of calcitonin receptor and PTH receptor. 5) KS increased the expression of PKA and PKC. 6) KS decreased the expression of $PLA_2$, COX, $PGE_2$ synthase, but increased prostacyclin synthase. 7) KS increased the expression of collagen(type IV) gene. It is concluded that KS might improve the osteoporosis resulted from augumentation of osteoblast proliferation and gene expression.

Keywords

References

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