The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Yangsaengwhallyukdan extract on Erectile Function in rat

양생활력단(養生活力丹) 추출물이 흰쥐의 음경발기에 미치는 영향

  • Lee, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Min, Gun-Woo (Dept. of Internal Medicine, Jain Oriental Hospital) ;
  • Shin, Hyeon-Cheol (Dept. of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 이철호 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 민건우 (자인한방병원 내과) ;
  • 신현철 (대구한의대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실)
  • Published : 2004.06.30
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Abstract

Objective : This study investigated the effects of Yangsaengwhallyukdan on nitrite oxide synthase (NOS) activity, nitrite level, antioxidation and erectile response in rat corpus cavernosum penis. Methods : Yangsaengwhallyukdan was formulated to contain various natural products that have been used to treat erectile dysfunction. Yangsaengwhallyukdan suspended in a 0.5% CMC solution was oral-administered, 50 mg or 100 mg per 1 kg of body weight for 30 days, while the normal group was administered only with a 0.5% CMC solution. The efficacy of the Yangsaengwhallyukdan was assessed with regard to erectile function. Results: After the Yangsaengwhallyukdan was administered to the rat for 30 days, the urethral NOS activity increased. The level of urethral nitrite, glutathione and testosterone increased too. The level of urethral lipid peroxide was decreased in Yangsaengwhallyukdan treated rats. The erectile response to a cavernous nerve stimulation in L-NAME$(10^4)$-treated rats in rats given Yangsaengwhallyukdan reached the level of the normal group. Conclusions : This study suggest that Yangsaengwhallyukdan is effective for the treatment of erectile dysfunction.

Keywords

References

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