The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Inhibitory Effect of Jaeumganghwa-tang on Allergic Inflammatory Reaction

자음강화탕(滋陰降火湯)의 알레르기성 염증반응억제(炎症反應抑制) 효과(效果)

  • Kim, Hong-Joon (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Woo-Sung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Park, Hyoung-Jin (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Goo (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Dong-Woung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Won, Jin-Hee (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Yu-Kyung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 김홍준 (원광대학교 한의과대학 비계내과학 교실) ;
  • 김우성 (원광대학교 한의과대학 비계내과학 교실) ;
  • 박형진 (원광대학교 한의과대학 비계내과학 교실) ;
  • 문구 (원광대학교 한의과대학 비계내과학 교실) ;
  • 김동웅 (원광대학교 한의과대학 비계내과학 교실) ;
  • 원진희 (원광대학교 한의과대학 비계내과학 교실) ;
  • 김유경 (원광대학교 한의과대학 비계내과학 교실)
  • Published : 2004.06.30
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Abstract

Object : This study investigates Jaeumganghwa-tang(JGT) has been used for the purpose of prevention and treatment of allergic inflammatory diseases. This study was to investigate the biological effects of JGT. Methods : Cytotoxcicity and inflammatory cytokines secretion with human mast cells(HMC-1) were examined. HMC-1 cells were stimulated with phorbol l2-myristate 13-acetate (PMA) and calcium ionophore A23l87. JGT by itself had no effect on cytotoxicity of HMC-1. The effects of JGT on the secretion of tumor necrosis factor-alpha(TNF-${\alpha}$) and interleukin(IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay(ELISA). Result : It was found that JGT inhibited PMA plus A23187-induced TNF-${\alpha}$ and IL-6 secretion. JGT also inhibited the $NF-{\kappa}$B(p50) expression. Conclusion : These results suggest that JGT inhibits the secretion of inflammatory cytokines in HMC-1 cells through blockade of $NF-{\kappa}B$ activation. Taken together, these effects support a role for JGT as a therapeutic agent in treatment of allergic inflammatory diseases such as asthma.

Keywords

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