The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Inhibition of mast cell-mediated immediate-type allergic reactions by Bojungikgitanggamibang

보중익기탕가미방(補中益氣湯加味方)에 의한 비만(肥滿) 세포(細胞) 매개성(媒介性) 즉각형(卽刻型) 알레르기 반응(反應)의 억제(抑制)

  • Choi, Jeong-On (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim, Jin-Man (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Seung-Eon (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Jo-Young (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Lee, Si-Hyeong (Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 최정온 (원광대학교 한의과대학 폐계내과학교실) ;
  • 김진만 (원광대학교 한의과대학 폐계내과학교실) ;
  • 이승언 (원광대학교 한의과대학 폐계내과학교실) ;
  • 신조영 (원광대학교 한의과대학 폐계내과학교실) ;
  • 이시형 (원광대학교 한의학 전문대학원)
  • Published : 2004.06.30
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Abstract

Objective : Mast cells are a potent source of mediators that regulate inflammatory response in allergies and asthma. The author studied the effect of Bojungikgitanggamibang(BITB) on mast cell-mediated anaphylactic reaction. Method : When BITB was given as pre-treatment at concentrations ranging from 0.01 to 1 mg/ml, the histamine release from rat peritoneal mast cells induced by compound 48/80 was reduced in a dose-dependent manner. Result : BITB dose-dependently inhibited compound 48/80-induced systemic anaphylactic shock. BITB also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE. In addition, BITB inhibited phorbol 12-myristate 13-acetate and A23187-induced interleukin-6 secretion from human mast cell line HMC-1 cells. Conclusion : These results indicate that BITB may be actively anti-allergic.

Keywords

References

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