Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Antidepressant effect of chunwangboshimdan and its influence on monoamines

천왕보심단(天王補心丹)의 항우울효과 및 monoamine 대사에 미치는 영향

  • Park Jong-Heum (Department of Herbal pharmacology, Collage of Oriental Medicine, Dongguk University) ;
  • Bae Chang-wook (Department of Herbal pharmacology, Collage of Oriental Medicine, Dongguk University) ;
  • Jun Hyun-Suk (Department of Herbal pharmacology, Collage of Oriental Medicine, Dongguk University) ;
  • Hong Sung-You (Department of Herbal pharmacology, Collage of Oriental Medicine, Dongguk University) ;
  • Park Sun-Dong (Department of Herbal pharmacology, Collage of Oriental Medicine, Dongguk University)
  • 박종흠 (동국대학교 한의과대학 방제학교실) ;
  • 배창욱 (동국대학교 한의과대학 방제학교실) ;
  • 전현숙 (동국대학교 한의과대학 방제학교실) ;
  • 홍성유 (동국대학교 한의과대학 방제학교실) ;
  • 박선동 (동국대학교 한의과대학 방제학교실)
  • Published : 2004.12.30
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Abstract

Depression is a sort of mental disorder which is very common. To treat depression, many drugs such as TCA, MAOI are developed and used. But they have a lot of side effects, so it needs to develop drugs without side effects or with less side effects. Herbal medicines have been used to treat diseases not only physical but also mental and have less side effects. therefore, it has been thoght the need to develop herbal medicine with antidepressant effect. The purpose of this study was to reseach antidepressant effect and influence on monoamines of chunwangboshimdan thought to have antidepressant according to ancient medical book- donguibogam- and recent reports. We used 'forced swimming test(FST)' to know antidepressant effect of chunwangboshimdan and HPLC to check the influence on monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) of chunwangboshimdan after divided into cerebral cortex, striatum, hypothalamus and hippocampus. The results were obtained as follows: In the study of antidepressant effect by 'forced swimming test(FST)'method, chunwang boshimdan had a significant antidepressant effect. In the study of influence on monoamines by HPLC, chunwangboshimdan mainly increased dopamine among monoamines and their metabolites(norepinephrine, dopamine, DOPAC, HVA, serotonin, 5-HIAA) significantly in 4 parts of rat's brain above-mentioned. Calculated by turnover ratio formulae of monoamine, chunwangboshimdan has more results than Imipramine. These results suggest that chunwangboshimdan has antidepressant effect that is related with the increase of monoamines by suppressing their metabolism as its mechanism.

Keywords

References

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