Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제30권4호
  • /
  • Pages.316-322
  • /
  • 2004
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
권호 표지

발치 후 즉시 임플란트 식립시 이식된 hBMP-I의 조직학적 고찰

THE HISTOLOGIC STUDY OF THE GRAFTED hBMP-I FOR IMMEDIATE IMPLANT FIXATION

  • 이은영 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 김경원 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 최희원 (충북대학교 의과대학 구강악안면외과학교실, 의학연구소) ;
  • 엄인웅 (한국조직은행) ;
  • 정호용 (인치과크리닉)
  • Lee, Eun-Young (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Kim, Kyoung-Won (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Choi, Hee-Won (Dept. of Oral & Maxillofacial Surgery, College of Medicine and Medical Research Institute, Chungbuk National University) ;
  • Um, In-Woong (Korea Tissue Bank) ;
  • Chung, Ho-Yong (In-Dental Clinic)
  • 발행 : 2004.08.31
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초록

A low molecular weight component named bone morphogenetic protein(BMP) chemically isolated from the organic matrix of bone, induce postfetal connective tissue cells surrounding small blood vessels to differentiate into cartilage and bone. The end product of BMP is a spherical ossicle of lamella bone filled with red bone marrow for the functional loading. This is a important point that the graft material is embedded the defect site during the implant surgery. Because present knowledge of the relationship between BMP and bone regeneration arises mainly from studies of induced bone formation in heterotopic sites, it would be helpful to determine whether BMP plays any part in the process of bone healing. The BMPs have been shown to play crucial roles in normal skeletal development as well as bone healing and are able to activate transcription of genes involved in cellular migration, proliferation, and differentiation. The delivery of BMP on matrices has been efficacious in the treatment of defect bone in implant surgery. The purpose of the histologic study was to evaluate the effect of DLB(demineralized lyophilized bone) coated with purified human BMP(hBMP-I) in immediate implant surgery with bony defect to obtain the functional structure of implant asap. The ability of a graft of hBMP-I to accelerate bony defect repair provides a rationale for its use in immediate implant surgery that have large bone defect in edentulous area.

키워드

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