Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Hepatoprotective activity of Indigofera aspalathoides extract against CCl4-induced liver damage

  • Gupta, M. (Department of Pharmaceutical Technology, Jadavpur University) ;
  • Mazumder, U.K. (Department of Pharmaceutical Technology, Jadavpur University) ;
  • Haldar, P.K. (Gupta College of Technological Sciences) ;
  • Manikandan, L. (Department of Pharmaceutical Technology, Jadavpur University) ;
  • Senthilkumar, G.P. (Department of Pharmaceutical Technology, Jadavpur University) ;
  • Kander, C.C. (Gupta College of Technological Sciences)
  • Published : 2004.06.30
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Abstract

The plant Indigofera aspalathoides are used by a large number of tribes in India for the treatment of various hepatic disorder. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its effect on carbontetrachloride $(CCl_{4})$ induced liver damage. Biochemical parameters such as serum glutamine oxaloacetate trasaminase (SGOT), serum glutamine pyruvate transaminase (SGPT), serum alkaline phosphatase (ALP), total serum protein (TP), thiobarbituric acid reactive substances (TBRS) and glutathione content of the liver were estimated to assess liver function and metabolism. Biochemical observations suggest that methanol extract of Indigofera aspalathoides (MEIA) significantly restored the liver function and metabolism towards normal condition in $CCl_{4}$-induced hepatic damage.

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References

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