Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Acupuncture treatment of drug addiction

  • Oh, Jin-Kyung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Chae, Youn-Byoung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Shim, In-Sop (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University) ;
  • Park, Hi-Joon (Department of Acupuncture and Meridian, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Hye-Jung (Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University)
  • Published : 2004.06.30
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Abstract

Acupuncture as a therapeutic intervention has been widely used for treatment for many functional disorders, such as substances abuse and mental dysfunction. In general, acupuncture is known to be simple, economic; painless, non-traumatic, and without untoward reaction, being able to inhibit the abstinence syndrome. Although a number of studies on acupuncture have been reported, a few studies described acupuncture effect on drug addiction. Evidences suggest that substances abuses including nicotine, cocaine and alcohol are in part related to its effects on dopamine neurons in the reward pathways of the brain. The effects of acupuncture on drug addiction may be mediated through the neuronal cells within the limbic structures, which are known to be involved in rewarding properties of drug abuse. This essay reviews clinical and experimental evidences for its effectiveness on the drug addiction, and discusses a plausible explanation for the mechanism of acupuncture on substances abuse.

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References

  1. Avants SK, Margolin A, Holford TR, Kosten TR. (2000) A randomized controlled trial of auricular acupuncture for cocaine dependence. Arch. Intern. Med. 160, 2305-2312. https://doi.org/10.1001/archinte.160.15.2305
  2. Bradberry CW, Roth RH. (1989) Cocaine increases extracellular dopamine in rat nucleus accumbens and ventral tegmental area as shown by in vivo microdialysis. Neurosci. Left. 103, 97-102. https://doi.org/10.1016/0304-3940(89)90492-8
  3. Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E. (2002) Role of dopamine D2-like receptors in cocaine selfadministration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J. Neurosci.22, 2977-2988.
  4. Chae Y, Yang CH, Kwon YK, Kim MR, Pyun KH, Hahm DH, Lee HJ, Shim I. (2004) Acupuncture attenuates repeated nicotine-induced behavioral sensitization and c-Fos expression in the nucleus accumbens and striatum of the rat. Neurosci. Left. 358, 87-90. https://doi.org/10.1016/j.neulet.2003.12.121
  5. Clark PB. (1990) Mesolimbic dopamine activation-the key to nicotine reinforcement? Ciba Found Symp. 152, 153-162.
  6. Dani JA, De Biasi M. (2001) Cellular mechanisms of nicotine addiction. Pharmacol. Biochem. Behav. 70, 439-446. https://doi.org/10.1016/S0091-3057(01)00652-9
  7. Gorelick D. (1993) Overview of pharmacologic treatment approaches for alcohol and other drug addiction: Intoxication, withdrawal, and relapse prevention. Psychiatric Clinics of North America 16, 141-156.
  8. George A. Ulett, Songping Han, Ji-sheng Han. (1998) Electroacupuncture: Mechanisms and Clinical Application. Society of Biological Psychiatry 44, 129-138. https://doi.org/10.1016/S0006-3223(97)00394-6
  9. Han JS, Zhang RL. (1993) Suppression of morphine abstinence syndrome by body electroacupuncture of different frequencies in rats. Drug Alcohol Depend. 31, 169-175. https://doi.org/10.1016/0376-8716(93)90069-3
  10. Jiang A, Cui M. (1994) Analysis of therapeutic effects of acupuncture on abstinence from smoking. J. Tradit. Chin. Med. 14, 56-63.
  11. Kim JH, Chung JY, Kwon YK, Kim KJ, Yang CH, Hahm DH, Lee HJ, Shim I. Acupuncture reduces alcohol withdrawal syndrome and c-Fos expression in rat brain (In preparation). https://doi.org/10.1142/S0192415X0500348X
  12. Lee B, Lee HJ, Hahm D, Shim I. Effect of herbal-acupuncture on repeated cocaine-induced behavioral and neurochemical sensitization in the rat (In preparation). https://doi.org/10.3831/KPI.2004.7.1.053
  13. Lee BB, Shim IS, Yang CH, Lee HI, Hahm DH, Lee HJ. (2002) Effect of acupuncture (HT7) on acute cocaine-induced locomotor activity and Fos-like immunoreactivity in the brain of the rats. J. Kor Meridian and Acupoint. 19, 25-33.
  14. Lee H, Ernst E. (2004) Acupuncture for labor pain management; A systematic review. Am. J. Obstet. Gynecol.. (in press)
  15. Margolin A, Kleber HD, A vants SK, Konefal J, Gawin F, Stark E, Sorensen J, Midkiff E, Wells E, Jackson TR, Bullock M, Culliton PD, Boles S, Vaughan R. (2002) Acupuncture for the treatment of cocaine addiction: a randomized controlled trial. JAMA. 287, 55-63. https://doi.org/10.1001/jama.287.1.55
  16. NIH Consensus Conference. Acupuncture. (1998) JAMA. 280, 1518-1524. Review. https://doi.org/10.1001/jama.280.17.1518
  17. Otto KC. (2003) Acupuncture and substance abuse: a synopsis, with indications for further research. Am. J. Addict. 12, 43-51. https://doi.org/10.1111/j.1521-0391.2003.tb00538.x
  18. Pidoplichko VI, DeBiasi M, Williams JT, Dani JA. (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390, 401-404. https://doi.org/10.1038/37120
  19. Ritz MC, Cone EJ, Kuhar MJ. (1990) Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study. Life Sci. 46, 635-645. https://doi.org/10.1016/0024-3205(90)90132-B
  20. Schenk S, Partridge B, Shippenberg TS. (1999) U69593, a kappa-opioid agonist, decreases cocaine self-administration and decreases cocaine-produced drug-seeking. Psychopharmacology. 144, 339-346. https://doi.org/10.1007/s002130051016
  21. Shim I, Javaid JI, Wirtshafter D, Jang SY, Shin KH, Lee HJ. (2001) Nicotine-induced behavioral sensitization is associated with extracellular dopamine release and expression of c-Fos in the striatum and nucleus accumbens of the rat. Behav. Brain Res. 121, 137-147. https://doi.org/10.1016/S0166-4328(01)00161-9
  22. Steiner H, Gerfen CR. (1998) Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Exp Brain Res. 123, 60-76. https://doi.org/10.1007/s002210050545
  23. Sytinsky I, Galebskaya L. (1979) Physiolo-biochemical basis of drug dependence treatment by acupuncture. Addictive Behavior 4, 137-141.
  24. ter Riet G, Kleijnen J, Knipschild P. (1990) Acupuncture and chronic pain: a criteria-based meta analysis. J Clin Epidemiol. 43, 1191-1199. https://doi.org/10.1016/0895-4356(90)90020-P
  25. Trumpler F, Oez S, Stahli P, Brenner HD, Juni P. (2003) Acupuncture for alcohol withdrawal: A randomized controlled trial. Alcohol & Alcoholism 38, 369-375. https://doi.org/10.1093/alcalc/agg091
  26. Weddington W. (1993) Cocaine. Diagnosis and treatment. Psychiatric Clinics of North America 16, 87-95.
  27. Wen LZ, Cheung SYC. (1973) Treatment of drug addiction by acupuncture and electrical stimulation. Asian J. Med. 9, 138-141.
  28. Wen H, Ho W, Ling N, Ma L, Choa G. (1979) The influence of electroacupuncture on naloxone-induced morphine withdrawal? Elevation of immuno-assayable beta-endorphin activity in brain but not in blood. Am. J. Chin. Med. 7, 237-239. https://doi.org/10.1142/S0192415X79000192
  29. White AR, Rampes H, Ernst E. (2002) Acupuncture for smoking cessation. Cochrane Database Syst Rev. CD000009.
  30. Yoon SS, Kwon YK, Kim MR, Shim I, Kim KJ, Lee MH, Golden GT, Yang CH. (2004) Acupuncture-mediated inhibition of ethanol induced dopamine release in the rat nucleus accumbens through the $GABA_B$ receptor. Neurosci. Lett. (in press)
  31. Yoshimoto K, Kato B, Sakai K, Shibata M, Yano T, Yasuhara M. (2001) Electroacupuncture stimulation suppresses the increase in alcohol-drinking behavior in restricted rats. Alcohol Clin. Exp. Res. 25, 63-68. https://doi.org/10.1111/j.1530-0277.2001.tb02421.x