Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antioxidative Effects of Polyozellin and Thelephoric Acid Isolated from Polyozellus multiflex

까치버섯(Polyozellus multiplex)으로부터 분리한 polyozellin과 thelephoric acid의 항산화 활성

  • Chung, Shin-Kyo (Department of Food Science & Technology, Kyungpook National University) ;
  • Jeon, So-Young (Division of Applied Biology & Chemistry, Kyungpook National University) ;
  • Lee, Hee-Ju (Division of Applied Biology & Chemistry, Kyungpook National University) ;
  • Kim, Suk-Kyung (Department of Food Science & Technology, Kyungpook National University) ;
  • Kim, Sang-In (Division of Applied Biology & Chemistry, Kyungpook National University) ;
  • Kim, Geum-Soog (Industrial Crop Division, National Crop Experiment, RDA) ;
  • Kwon, Soon-Ho (Division of Applied Biology & Chemistry, Kyungpook National University) ;
  • Kim, Ja-Young (Division of Applied Biology & Chemistry, Kyungpook National University) ;
  • Song, Kyung-Sik (Division of Applied Biology & Chemistry, Kyungpook National University)
  • 정신교 (경북대학교 식품공학과) ;
  • 전소영 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 이희주 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 김숙경 (경북대학교 식품공학과) ;
  • 김상인 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 김금숙 (작물시험장 특용작물과) ;
  • 권순호 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 김자영 (경북대학교 농업생명과학대학 응용생물화학부) ;
  • 송경식 (경북대학교 농업생명과학대학 응용생물화학부)
  • Published : 2004.06.30
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Abstract

In the course of screening for reactive oxygen species scavengers from natural products, two antioxidants were isolated from the edible mushroom Polyozellus multiflex and identified as polyozellin and thelephoric acid. Thelephoric acid inhibited 45.7% of the super oxide anion radical, 74.6% of the hydroxyl radical, and 44.0% of the DPPH radical at 0.1 mM, while the positive control ${\alpha}-tocopherol$ did 22.1%, 75.6%, and 26.5% of each radical, respectively. Polyozellin, the reductive acetylated form of thelephoric acid, showed almost same scavenging activity against above mentioned radicals. The isolated compounds showed scavenging activity on the superoxide anion radical in the ESR method ($IC_{50}$ of polyozellin and thelephoric acid were $218.0\;{\mu}M$ and $21.1\;{\mu}M$, respenctively). However, they showed no significant activity on the hydrogen peroxide radical.

Keywords

References

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