Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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Statistical Interpretation of Bioequivalence in 2 × 2 Crossover Design with Missing Observations

2 × 2 교차설계에 의한 생물학적동등성시험에서 결측치가 있을 때의 통계적 해석 방법

  • Published : 2004.10.20
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Abstract

Statistical interpretations in a bioequivalence trial are considered and studied when the missing observations occurred in $2\;{\times}\;2$ crossover experiment. Patel (1985) suggested the approximate test procedures for carryover effect and drug effect in $2\;{\times}\;2$ crossover design when some of data are missing in the second period. A modified Patel method is newly proposed to the bioequivalence trial and it is compared with the current method through the simulation study.

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References

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