한국약용작물학회지 (Korean Journal of Medicinal Crop Science)

  • 제12권4호
  • /
  • Pages.315-320
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  • 2004
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  • 1225-9306(pISSN)
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  • 2288-0186(eISSN)
한국약용작물학회 (The Korean Society of Medicinal Crop Science)
권호 표지

와송(瓦松) 추출물이 면역체계에 미치는 영향

Effects of Orostachys japonicus A. Berger on the Immune System

  • 권진 (군장대학 의무행정과) ;
  • 한광수 (우석대학교 허브자원학과)
  • Kwon, Jin (Dept. of Medical Administration, Kunjang College) ;
  • Han, Kwang-Soo (Dept. of Herb Resource, Woosuk University)
  • 발행 : 2004.09.30
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초록

와송 (OJB)의 면역 및 항암 효과를 관찰한 결과, 와송은 생쥐의 비장 및 흉선세포의 생존율을 증가시켰으며, 임파구 아집단분석 결과 비장 T세포를 유의성있게 증가시켰는데 비장 T세포 중의 $T_H$세포 및 Tc세포가 모두 증가되었고, 혈청 중 ${\gamma}-interferon$의 생성을 현저하게 증가시켰다. 또한 와송은 L1210세포 및 U937세포 등의 백혈병세포의 아폽토시스를 촉진시키는 항암능력을 보유하고 있었다.

The purpose of this research was to investigate the effect of Orostachys japonicus A. Berger (OJB) on the immune system. Administration of OJB (500 mg/kg) enhanced viability of splenocytes and thymocytes in BALB/c mice, and also OJB increased of splenic T lymphocytes, significantly, increased CD4 positive $T_H$ cells and CD8 positive Tc cells. OJB markedly, enhanced the production of ${\gamma}-interferon$ in mice serum. OJB accelerated the apoptosis of L1210 and U937 leukemia cells and increased the expression of apoptosis-related ICE, c-myc, p53 gene. These results suggest that OJB have an immuno-regulatory and anti-cancer activity.

키워드

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