Comparison of Resveratrol Contents in Medicinal Plants

  • Lim, Jung-Dae (College of Agriculture and Life Science, Kangwon National University) ;
  • Yun, Song-Joong (Division of Biological Resources Science, Chonbuk Natl. Univ.,) ;
  • Lee, Sun-Ju (College of Life and Environment Science, Konkuk University) ;
  • Chung, Ill-Min (College of Life and Environment Science, Konkuk University) ;
  • Kim, Myong-Jo (College of Agriculture and Life Science, Kangwon National University) ;
  • Heo, Kweon (College of Agriculture and Life Science, Kangwon National University) ;
  • Yu, Chang-Yeon (College of Agriculture and Life Science, Kangwon National University)
  • 발행 : 2004.05.30

초록

Secondary phenolic metabolites play an important role in plant defense mechanisms, and increasing evidence indicates that many phenolic compounds are important in human health. To date, few studies have investigated the impact of various medicinal plants on levels of secondary plant metabolites. To address this issue, 82 species of Korean medicinal plants were screened to determine their resveratrol contents. Among 82 medicinal plants, 5 species such as Gardenia jasmonoides, Phlomis umbrosa, Rheum palmatum L., Polygala tenuifolia, Rubus chingii HU contained relatively high concentrations of resveratrol $(179.75{\sim}42.71\;{\mu}g/g)$. But, 40 species including Adenophora triphylla var. japonica HARA were only observed low concentrations or trace of resveratrol, and 20 species including Alpinia officinarum HANCE did not contain a resveratrol.

키워드

참고문헌

  1. Adrian M, Jeandet P, Breuil ACC, Levite D, Deborg S, Bessis R(2000) Assay of resveratrol and derivative stilbenes in wine by direct injection high performance liquid chromatography. Am. J. Enol. Vitic., 51(1):37-41
  2. Belguendouz L, Fremont L, Linard A (1997) Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins. Biochem. Pharmacol 53:1347-1355 https://doi.org/10.1016/S0006-2952(96)00820-9
  3. Bertelli AAE (1998) Modulatory effect of resveratrol, a natural phytoalexin, on endothelial adhesion molecules and intracellular signal transduction. Pharmaceut. Biol. 36:44-52
  4. Bertelli AAE, Giovaninni L, De Caterina F, Miglioni M, Bernini W, Fregoni M, Bavaresco J, Trevisan M, Bertelli A (1995) Antiplatelet activity of synthetic and natural resveratrol in red wine. Int. J. Tiss. React. 17:1-3
  5. Burns J, Yokota T, Ashihara H, Lean MEJ, Crozier A (2002) Plant foods and herbal sources of resveratrol. Journal of Agricultural and Food Chemistry 50: 3337-3340 https://doi.org/10.1021/jf0112973
  6. Cadenas S, Barja G (1999) Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO$_3$. Free Rad. Biol. Med. 26:1531-1537 https://doi.org/10.1016/S0891-5849(99)00019-2
  7. Cantos E, Garcia-Viguera C, De Pascual-Teresa S, Toms-Barbern FA (2000) Effect of postharvest ultraviolet irradiation on resveratrol and other phenolics of Cv. Napoleon table grapes. J. Agric. Food Chem. 48:4606-4612 https://doi.org/10.1021/jf0002948
  8. Carbo N, Costelli P, Baccino FM, Lopez-Soriano FJ, Argiles JM(1999) Resveratrol, a natural product present in wine, decreases tumour growth in a rat tumour model. Biochem. Biophys. Res. Commun. 254:739-743 https://doi.org/10.1006/bbrc.1998.9916
  9. Dong YH, Mitra D, Koostra A, Lister CE, Lancaster JE (1995) Postharvest stimulation of skin color in royal gala apple. J. Am. Soc. Hortic. Sci., 120:95-100
  10. Frankel EN, Waterhouse AL, Teissedre PL (1995) Principal phenolic phytochemicals in selected california wines and their antioxidant activity in inhibiting oxidation of human low density lipoproteins. J. Agr. Food Chem. 43:890-894 https://doi.org/10.1021/jf00052a008
  11. Fremont L (2000) Biological effects of resveratrol. Life Sci 66:663-673 https://doi.org/10.1016/S0024-3205(99)00410-5
  12. Gehm BD, McAndrews JM, Chien PY, Jameson JL (1997) Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc. Natl. Acad. Sci. USA. 94:14138-14143 https://doi.org/10.1073/pnas.94.25.14138
  13. Hale AJ, Smith CA, Sutherland LC, Stoneman VEA, Longthorne VL, Culhane AC, Williams GT (1996) Apoptosis: Molecular regulation of cell death. Eur. J. Biochem. 236:1-26 https://doi.org/10.1111/j.1432-1033.1996.00001.x
  14. Hopwood DA (1997) Genetic contributions to understanding polyketide synthases. Chem. Rev. 97:2365-2397
  15. Hopwood DA, Sherman DH (1990) Molecular genetics of polyketides and its comparison to fatty acid biosynthesis. Annu. Rev. Genet. 23:37-66
  16. Huang C, Ma WY, Goranson A, Dong Z (1999) Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. Carcinogenesis 20:237-242 https://doi.org/10.1093/carcin/20.2.237
  17. Hutchinson CR (1998) Combinatorial biosynthesis for new drug discovery. Curr. Opin. Microbiol. 1:319-329 https://doi.org/10.1016/S1369-5274(98)80036-2
  18. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Famsworth NR, Kinghom AD, Mehta RG,Moon RC, Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275:218-220 https://doi.org/10.1126/science.275.5297.218
  19. Kashiwada Y, Nonaka G, Nishioka I, Nishizawa M, Yamagishi T (1988) Studies on rhubarb (Rhei rhizoma). XIV. Stilbene glucosides. Chem. Pharm. Bull. 36:1545-1549 https://doi.org/10.1248/cpb.36.1545
  20. Kimura Y, Okuda H (2001) Resveratrol isolated from polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in lewis lung carcinoma-bearing mice. J. Nutr., June 1, 131(6):1844-1849 https://doi.org/10.1093/jn/131.6.1844
  21. Khosla C, Gokhale RS, Jacobsen JR, Cane DE (1999) Tolerance and specificity of polyketide synthases. Annu. Rev. Biochem 68:219-253 https://doi.org/10.1146/annurev.biochem.68.1.219
  22. Langcake P (1981) Disease resistance of Vitis spp. and the production of the stress metabolites resveratrol, v-viniferin, $\alpha$ https://doi.org/10.1016/S0048-4059(81)80043-4
  23. Maccarrone M, Lorenzon T, Guerrieri P, Agro AF (1999) Resveratrol prevents apoptosis in K562 cells by inhibiting lipoxygenase and cyclooxygenase activity. Eur. J. Biochem. 265:27-34 https://doi.org/10.1046/j.1432-1327.1999.00630.x
  24. Melzoch K, Filip V, Buckiov D, Hanzlikov I, Smidrkal J (2000) Resveratrol occurrence in wine originating from Czech vineyard regions and effect on human health. Czech. J. Food Sci. 18(1):35-40
  25. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis; implications for protection against coronary heart disease. Clin. Chim. Acta 235:207-219 https://doi.org/10.1016/0009-8981(95)06045-1
  26. Palomino O, Gmez-Serranillos MP, Slowing K, Carretero E, Villar A (2000) Study of polyphenols in grape berries by reversed-phase high-performance liquid chromatography. J. Chrom. A. 870:449-451 https://doi.org/10.1016/S0021-9673(99)01225-X
  27. Raiber S, Schrder G, Schrder J (1995) Molecular and enzymatic characterization of two stilbene synthases from Eastern white pine (Pinus strobus). A single Arg/His difference determines the activity and the pH dependence of the enzymes. PEBS Lett. 361:299-302
  28. Ray PS, Maulik G, Cordis GA, Bertelli AAE, Bertelli A, Das DK (1999) The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury. Free Rad. Biol. Med. 27:160-169 https://doi.org/10.1016/S0891-5849(99)00063-5
  29. Renauld S, De Lorgeril M (1992) Wine, alcohol, Platelets, and the French paradox for coronary heart disease. Lancet, 339:1523-1526 https://doi.org/10.1016/0140-6736(92)91277-F
  30. Schppner A, Kindl H (1984) Purification and properties of a stilbene synthase from induced cell suspension cultures of peanuts.J. Biol. Chem. 263:6806-6811
  31. Schanz S, Schrder G, Schrer J (1992) Stilbene synthase from Scots pine (Pinus sylvestris). FEBS Lett. 313:71-74 https://doi.org/10.1016/0014-5793(92)81187-Q
  32. Schrder J (1999) The chalcone/stilbene synthase-type family of condensing enzyme. In Comprehensive Natural Products Chemistry (Sankawa U., ed). 749-771. Elsevie, Oxford
  33. Sobolev VS, Cole RJ (1999) Trans-resveratrol content in commercial peanuts and peanut product. J. Agric. Food Chem. 47:1435-1439 https://doi.org/10.1021/jf9809885
  34. Spavoli F, Martin C, Scienza A, Gavazzi G, Tonelli C (1994) Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.) Plant Mol. Biol. 24:743-745 https://doi.org/10.1007/BF00029856
  35. Wang CJ, Chu CY, Tseng TH, Lin JK (1993) Penta-acetyl geniposide inhibits the growth and development of C-6 glioma cells in rats. Cancer Lett. 70:113-118 https://doi.org/10.1016/0304-3835(93)90082-K
  36. Zhu Y, Coury LA, Long H, Duda CT, Kissinger CB, Kissinger PT(2000) Liquid chromatography with multichanel electrochemical detection for the determination of resveratrol in wine, grape juice, and grape seed capsulen with automated solid phase extraction. J. Liq. Chrom. Rel. Technol., 23(10):1555-1564 https://doi.org/10.1081/JLC-100100434