Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Antioxidant Effects and Inhibitory Effect on NO Synthesis by Extracts of Canavalia lineata

해녀콩 (Canavalia lineata (THUNB.) DC.) 추출물의 항산화 효과 및 NO 생성 억제 효과

  • Bu, Hee-Jung (Department of Chemistry, Cheju National University) ;
  • Lee, Hye-Ja (Department of pharmacology, College of Medicine, Cheju National University) ;
  • Yoo, Eun-Sook (Department of pharmacology, College of Medicine, Cheju National University) ;
  • Jung, Duk-Sang (Department of Chemistry, Cheju National University) ;
  • Riu, Key-Zung (Division of Horticultural Life Science, Cheju National University) ;
  • Lee, Sun-Joo (Department of Chemistry, Cheju National University)
  • 부희정 (제주대학교 화학과) ;
  • 이혜자 (제주대학교 의과대학 약리학 교실) ;
  • 유은숙 (제주대학교 의과대학 약리학 교실) ;
  • 정덕상 (제주대학교 화학과) ;
  • 류기중 (제주대학교 원예생명과학부) ;
  • 이선주 (제주대학교 화학과)
  • Published : 2004.12.30
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Abstract

Scavenging effects of DPPH radical and hydroxyl radical, inhibition of linoleic acid oxidation, inhibition of NO synthesis and iNOS expression were tested with extracts and chromatographic subfractions of Canavalia lineata obtained at Jeju island. Chloroform extract and its subfractions gave moderate effects on scavenging DPPH radical and hydroxyl radical, They also inhibited linoleic acid oxidation, and NO synthesis. Inhibition of NO synthesis resulted from the repression of iNOS gene expression. Ethyl acetate extract and its subfractions showed excellent effects on scavenging DPPH radical and hydroxyl radical, while they were cytotoxic.

Keywords

References

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