Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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The Anxiolytic-like Effects of Scutellaria baicalensis Using Elevated Plus-Maze in Rats

Rat에서 Elevated plus-maze를 이용한 황금의 항불안 효과

  • Jung, Ji-Wook (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Ahn, Nam-Yoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Park, Sung-Hwan (Department of Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Oh, Jin-Kyung (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Oh, Hye-Rim (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Lee, Bo-Kyung (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Om, Ae-Son (Department of Food and Nutrition, College of Human Ecology, Hanyang University) ;
  • Kim, Beom-Soo (Nature Co., LTD.) ;
  • Kim, Dong-Hyun (Department of Pharmaceutical Science, College of Pharmacy, KyungHee University) ;
  • Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, KyungHee University)
  • Published : 2004.03.30
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Abstract

Scutellaria baicalensis Georgi is one of most important medicinal herbs in traditional chinese medicine. The object of this study was to determine the effects of the water extracts of Scutellaria baicalensis (SB) on the anxiolytic-like activities in the elevated plus-maze (EPM) test. The watεr extracts of SB (100, 200, or 400 mg/kg) were orally administered to male SD rats for 3 days, and behavioral tests for the anxiolytic activity were performed. SB (100, 200, or 400 mg/kg) significantly increased in time-spent and arm entries into the open arms of the EPM compared with the control group. Futhermore, those anxiolytic-like activities of SB were antagonized by flumazenil (a $GABA_A$ antagonist, 3 mg/kg), but not by pindolol (a $5-HT_{1A}$ antagonist, 10 mg/kg). SB did not cause myorelaxant effects in the horizontal wire test at any dosage regimen. Therefore, these findings suggest that SB promote the anxiolytic-like activity mediated by GABAergic nervous system in rats.

Keywords

References

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