Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Activity of (8E,13Z,20Z)-Strobilinin/(7E,13Z,20Z)-Felixinin from a Marine Sponge Psammocinia sp.

  • Jiang, Ya-Hong (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University) ;
  • Ryu, Seung-Hee (Department of Chemistry and Biohealth Products Research Center, Inje University) ;
  • Ahn, Eun-Young (Department of Chemistry and Biohealth Products Research Center, Inje University) ;
  • You, Song (School of Pharmaceutical Engineering, Shenyang Pharmaceutical University) ;
  • Lee, Burm-Jong (Department of Chemistry and Biohealth Products Research Center, Inje University) ;
  • Jung, Jee-H (College of Pharmacy, Pusan National University) ;
  • Kim, Dong-Kyoo (Department of Chemistry and Biohealth Products Research Center, Inje University)
  • Published : 2004.12.30
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Abstract

During the course of our screening for bioactive metabolites from marine sponges, EZZ, the inseparable 1:1 mixture of (8E,13Z,20Z)-strobilinin and (7E,13Z,20Z)-felixinin has been found to deliver significant cytotoxicity against some cancer cell lines. In this study, the antioxidant activity of EZZ was first time evaluated by a series of antioxidant assays. It was found that EZZ was weak in scavenging the stable free radical 1,1-diphenyl-2-picrylhyrazyl (DPPH), but it was comparable to ascorbic acid in scavenging ABTS and superoxide radicals. In addition, EZZ could protect DNA from hydroxyl radical-induced strand cleavage. The findings of the present study suggest that EZZ possess certain antioxidant activity, which might help to prevent occurrence of cancer by alleviating the oxidative stress in cells.

Keywords

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