Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antiallergic and Anti-asthmatic Activities of the Alcoholic Extract of Terminalia arjuna and Arjunolic Acid

  • Prasad, M.V.V. (Department of Pharmaceutical Chemistry, Dr. HCT College of Pharmacy) ;
  • Anbalagan, N. (Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy) ;
  • Patra, A. (Department of Chemistry, University College of Science) ;
  • Veluchamy, G. (Central Research Institute for Siddha) ;
  • Balakrishna, K. (Central Research Institute for Siddha)
  • Published : 2004.10.30
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Abstract

In the present study, the alcoholic extract of Terminalia arjuna (TA) and Arjunolic acid (AA) were studied fur its anti-asthmatic and anaphylactic activity. Treatment with TA (250 & 500 mg/kg) and AA (50 & 100 mg/kg) has shown significant protection against mast cell disruption in rats induced by compound 48/80. TA and AA also protected the guinea pig against histamine as well as acetylcholine induced bronchospasm. Both TA & AA exhibited better protection against histamine release than against acetylcholine release. Anti-asthmatic and anaphylactic activity may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release.

Keywords

References

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