Phytochemical Studies of Phyllanthus debilis

  • Chandrashekar, K.S. (Department of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences) ;
  • Satyanarayana, D. (Department of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences) ;
  • Joshi, A.B. (Department of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences) ;
  • Subrahmanyam, E.V.S. (Department of Pharmacognosy, N.G.S.M Institute of Pharmaceutical Sciences)
  • Published : 2004.06.30

Abstract

Two Lignans Phyllanthin and Hypophyllanthin, and a steroid ${\beta}-sitosterol$ has been isolated from the leaves of Phyllanthus debilis and their structures were established by spectral analysis and direct comparison with authentic samples. This is the first report of occurrence of these compound from P.debilis.

Keywords

References

  1. Aimon, S., Siriporn, N., and Chulabhorn, M., $^1$H and $^13$C-NMR assignment of phyllanthin and hypophyllanthin. J. Nat. Prod. 56, 2, 233-239 (1993) https://doi.org/10.1021/np50092a008
  2. Indira Balachandran and V.V. Sivarajan: Ayurvedic drugs and their plant sources, 1$^{st}$ Edition, Oxford and 1BH Publishing company Pvt. Ltd, New Delhi (1994)
  3. Row, L.R., Satyanarayana, R., and Srivasulu, C., Crystalline constituents of euphorbiaceae XI. Tetrahedron. 26, 3051-3057 (1970) https://doi.org/10.1016/S0040-4020(01)92887-X
  4. Sane, R.T., Kuber, V.V., Challisary, M.S., Menon, S., Hepato-protection by Phyllanthus amarus and Phyllanthus debilis in CCl$_4$ induced liver dysfunction, Current Sciences, 68, 1243-1246 (1995)
  5. Shah, M., Patel, R., Phadke, M., Menon, S., Francis, M., and Sane, R.T., Evaluation of the effect of aqueous extract from powders of root, stem, leaves and whole plant of Phyllanthus debilis against carbontetrachloride induced rat liver dysfunction. Indian Drugs, 39, 2002
  6. Shah, M., Patel, P., Phadke, M., Menon, S., and Sane, R.T., Hepatoprotective action of extracts of Phyllanthus debilis in various solvents. Bioresearch Journal, 2, 11-23 (1999)
  7. The Wealth of India Raw materials, CSIR, New Delhi, Vo1-3, 34 (1950)