References
- Armour KJ, Armour KE, van't Hof RJ, Reid DM, Wei XQ, Liew FY, Ralston SH. Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis. Arthritis Rheum 44: 2790-2796, 2001 https://doi.org/10.1002/1529-0131(200112)44:12<2790::AID-ART466>3.0.CO;2-X
- Boileau C, Martel-Pelletier J, Moldovan F, Jouzeau JY, Netter P, Manning PT, Pelletier JP. The in situ up-regulation of chond- rocyte interleukin-1-converting enzyme and interleukin-18 levels in experimental osteoarthritis is mediated by nitric oxide. Arthritis Rheum 46: 2637-2647, 2002 https://doi.org/10.1002/art.10518
- Chae HJ, Chae SW, Kang JS, Bang BG, Cho SB, Park RK, So HS, Kim YK, Kim HM, Kim, HR. Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. Endocrinology 141: 2904-2913, 2000a https://doi.org/10.1210/en.141.8.2904
- Chae HJ, Kang JS, Byun JO, Han KS, Kim DU, Oh SM, Kim HM, Chae SW, Kim HR. Molecular mechanism of staurosporineinduced apoptosis in osteoblasts. Pharmacol Res 42: 373-381, 2000b https://doi.org/10.1006/phrs.2000.0700
- Farrell AJ, Blake DR, Palmer RMJ, Moncada S. Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Ann Rheum Dis 51: 1219-1222, 1992 https://doi.org/10.1136/ard.51.11.1219
- Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 96: 1631-1638, 1995 https://doi.org/10.1172/JCI118202
- Forstermann U, Kleinert H. Nitric oxide synthase: expression and expressional control of the three isoforms. Naunyn Schmiedebergs Arch Pharmacol 352: 351-364, 1995
- Fox SW, Chow JW. Nitric oxide synthase expression in bone cells. Bone 23: 1-6, 1998 https://doi.org/10.1016/S8756-3282(98)00070-2
- Grabowski PS, England AJ, Dykhuizen R, Copland M, Benjamin N, Reid DM, Ralston SH. Elevated nitric oxide production in rheumatoid arthritis. Detection using the fasting urinary nitrate: creatinine ratio. Arthritis Rheum 39: 643-647, 1996a https://doi.org/10.1002/art.1780390416
- Grabowski PS, Macpherson H, Ralston SH. Nitric oxide production in cells derived from the human joint. Br J Rheum 35: 207-212, 1996b https://doi.org/10.1093/rheumatology/35.3.207
- Grabowski PS, Wright PK, van't Hof RJ, Helfrich MH, Oshima H, Ralston SH. Immunolocalisation of inducible nitric oxide synthase in the synovium and cartilage in rheumatoid arthritis and osteoarthritis. Br J Rheumatol 36: 651-655, 1997 https://doi.org/10.1093/rheumatology/36.6.651
- Hilliquin P, Borderie D, Hernvann A, Menkes CJ, Ekindjian OG. Nitric oxide as S-nitrosoproteins in rheumatoid arthritis. Arthritis Rheum 40: 1512-1517, 1997. https://doi.org/10.1002/art.1780400820
- Hukkanen M, Hughes FJ, Buttery LD, Gross SS, Evans TJ, Seddon S, Riveros-Moreno V, Macintyre I, Polak JM. Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology 136: 5445-5453, 1995 https://doi.org/10.1210/en.136.12.5445
- Ialenti A, Moncada S, Di Rosa M. Modulation of adjuvant arthritis by endogenous nitric oxide. Br J Pharmacol 110: 701-706, 1993 https://doi.org/10.1111/j.1476-5381.1993.tb13868.x
- Ihbe A, Baumann G, Heinzmann U, Atkinson MJ. Loss of the differentiated phenotype precedes apoptosis of ROS 17/2.8 osteoblast-like cells. Calcif Tissue Int 63: 208-213, 1998 https://doi.org/10.1007/s002239900516
- Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC. Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257: 88-91, 1992 https://doi.org/10.1126/science.1621100
- Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res 13: 793-802, 1998 https://doi.org/10.1359/jbmr.1998.13.5.793
- Kang YJ, Koo EB, Lee YS, Yun-Choi HS, Chang KC.Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol 128: 357-364, 1999a https://doi.org/10.1038/sj.bjp.0702787
- Kang YJ, Lee YS, Lee GW, Lee DH, Ryu JC, Yun-Choi HS, Chang KC. Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root. J Pharmacol Exp Ther 291: 314-320, 1999b
- Kang YJ, Seo SJ, Yun-Choi HS, Lee DH, Kim YM,Chang KC. A synthetic isoquinoline alkaloid, 1-(beta-naphthylmethyl)-6,7- dihydroxy-1,2,3,4-tetrahydroisoquinoline (YS 51), reduces inducible nitric oxide synthase expression and improves survival in a rodent model of endotoxic shock. J Pharmacol Exp Ther 301: 561-567, 2002 https://doi.org/10.1124/jpet.301.2.561
- Manolagas SC, Jilka RL. Mechanisms of disease: bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332: 305-311, 1995 https://doi.org/10.1056/NEJM199502023320506
- McCartney-Francis N, Allen JB, Mizel DE, Albina JE, Xie QW, Nathan CF, Wahl SM. Suppression of arthritis by an inhibitor of nitric oxide synthase. J Exp Med 178: 749-754, 1993 https://doi.org/10.1084/jem.178.2.749
- Mogi M, Kinpara K, Kondo A, Togari A. Involvement of nitric oxide and biopterin in proinflammatory cytokine-induced apoptotic cell death in mouse osteoblastic cell line MC3T3-E1. Biochem Pharmacol 58: 649-654, 1999 https://doi.org/10.1016/S0006-2952(99)00131-8
- Mogi M, Kondo A, Kinpara K, Togari A. Anti-apoptotic action of nerve growth factor in mouse osteoblastic cell line. Life Sci 67: 1197- 1206, 2000 https://doi.org/10.1016/S0024-3205(00)00705-0
- Murrell GA, Jang D, Williams RJ. Nitric oxide activates metalloprotease enzymes in articular cartilage. Biochem Biophys Res Commun 206: 15-21, 1995 https://doi.org/10.1006/bbrc.1995.1003
- Nakajima T, Aono H, Hasunuma T, Yamamoto K, Shirai T, Hirohata K, Nishioka K. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 38: 485- 491, 1995 https://doi.org/10.1002/art.1780380405
- Niederberger E, Tegeder I, Schafer C, Seegel M, Grosch S, Geisslinger G. Opposite effects of rofecoxib on nuclear factor-kappa B and activating protein-1 activation. J Pharmacol Exp Ther 304: 1153-1160, 2003. https://doi.org/10.1124/jpet.102.044016
- Palmer RM, Hickery MS, Charles IG, Moncada S, Bayliss MT. Induction of nitric oxide synthase in human chondrocytes. Biochem Biophys Res Commun 193: 398-405, 1993 https://doi.org/10.1006/bbrc.1993.1637
- Parfitt AM. Bone-forming cells in clinical conditions. In Bone. Volume 1: the osteoblast and osteocyte. BK Hall, editor. Telford Press and CRC Press. Boca Raton, FL 351-429, 1990
- Pelletier JP, Fernandes JC, Jovanovic DV, Reboul P, Martel- Pelletier J. Chondrocyte death in experimental osteoarthritis is nitric oxide synthase. J Rheumatol 11: 2509-2519, 2001
- Ralston SH, Grabowski PS. Mechanisms of cytokine induced bone resorption: Role of nitric oxide, cyclic guanosine monophosphate, and prostaglandins. Bone 19: 29-33, 1996 https://doi.org/10.1016/8756-3282(96)00101-9
- Ralston SH, Todd D, Helfrich M, Benjamin N, Grabowski PS. Human osteoblast-like cells produce nitric oxide and express inducible nitric oxide synthase. Endocrinology 135: 330-336, 1994 https://doi.org/10.1210/en.135.1.330
- Sakurai H, Kohsaka H, Liu MF, Higashiyama H, Hirata Y, Kanno K, Saito I, Miyasaka N. Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritis. J Clin Invest 96: 2357-2363, 1995 https://doi.org/10.1172/JCI118292
- Sioud M, Mellbye O, Forre O. Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin Exp Rheumatol 16: 125-134, 1998
- Stadler J, Stefanovic-Racic M, Billiar TR, Curran RD, McIntyre LA, Georgescu HI, Simmons RL, Evans CH. Articular chondrocytes synthesize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 147: 3915-3920, 1991
- Stefanovic-Racic M, Meyers K, Meschter C, Coffey JW, Hoffman RA, Evans CH. N-monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats. Arthritis Rheum 37: 1062-1069, 1994 https://doi.org/10.1002/art.1780370712
- Taskiran D, Stefanovic-Racic M, Georgescu H, Evans C. Nitric oxide mediates suppression of cartilage proteoglycan synthesis by interleukin-1. Biochem Biophys Res Commun 200: 142-148, 1994 https://doi.org/10.1006/bbrc.1994.1426
-
Tom VK, Schotland S, Green J. Inflammatory cytokines (IL-1alpha, TNF-alpha) and LPS modulate the Ca
$^{2+}$ signaling pathway in osteoblasts. Am J Physiol 274: C1686-1698, 1998 https://doi.org/10.1152/ajpcell.1998.274.6.C1686 - Wang E A, Rosen V, D'Alessandro JS, Beuduy M, Cordes P, Harada T, Israel DI, Hewick RM, Kerns KM, Lapan P, Luxenberg DP, Mcquaid D, Moutsatsos KI, Nove J, Wozney JM. Recombinant human bone morphogenetic protein induces bone formation. Proc Natl Acad Sci USA 87: 2220-2224, 1990. https://doi.org/10.1073/pnas.87.6.2220
- Wei XQ, Charles IG, Smith A, Ure J, Feng GJ, Huang FP, Xu D, Muller W, Moncada S, Liew FY. Altered immune response in mice lacking inducible nitric oxide synthase. Nature 375: 408- 411, 1995 https://doi.org/10.1038/375408a0
- Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids: potential mechanisms of their deleterious effects on bone. J Clin Invest 102: 274-282, 1998 https://doi.org/10.1172/JCI2799
- Wetterwald A, Hoffstetter W, Cecchini MG, Lanske B, Wagner C, Fleisch H, Atkinson M. Characterization and cloning of the E11 antigen, a marker expression by rat osteoblasts and osteocytes. Bone 18: 125-132, 1996 https://doi.org/10.1016/8756-3282(95)00457-2
- Yamaguchi A, Katagiri T, Ikeda T, Wozney JM, Rosen V, Wang EA, Kahn AJ, Suda T, Yoshiki S. Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro. J Cell Biol 113: 681- 687, 1991 https://doi.org/10.1083/jcb.113.3.681
- Yudoh K, Matsuno H, Nakazawa F, Katayama R, Kimura T. Recon stituting telomerase activity using the telomerase catalytic subunit prevents the telomere shorting and replicative senescence in human osteoblasts. J Bone Miner Res 16: 1453-1464, 2001 https://doi.org/10.1359/jbmr.2001.16.8.1453
- Yun-Choi HS, Pyo M K, Park KM, Chang KC, Lee DH. Antithrombotic effects of YS-49 and YS-51S-1-naphthylmethyl analogs of higenamine. Thromb Res 301: 561-567, 2001