The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 25 Issue 4
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- Pages.260-273
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- 2004
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- 1226-9174(pISSN)
A Study the Effects of Three Preparations of Hirudo on the Expression of Pro-inflammatory Cytokines in Human Bronchial Epithelial Cells Line BEAS-2B
수질(水蛭)의 제법(制法)에 따른 BEAS-2B 인간(人間) 기관지상피세포(氣管支上皮細胞)의 염증유발성(炎症誘發性) Cytokines 발현(發顯)에 미치는 영향(影響)
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Jung, Hee-Jae
(Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
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Jung, Sung-Ki
(Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Rhee, Hyung-Koo (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Han, Dong-Ha (Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
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정희재
(경희대학교 한의과대학 폐계내과학교실) ;
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정승기
(경희대학교 한의과대학 폐계내과학교실) ;
- 이형구 (경희대학교 한의과대학 폐계내과학교실) ;
- 한동하 (경희대학교 한의과대학 폐계내과학교실)
- Published : 2004.12.30
Abstract
Backgrounds : In recent years, asthma has become recognized as a chronic inflammatory disease associated pathologically with airway epithelial inflammation and airway remodeling. Objectives : To evaluate the different effects of Hirudo depending upon pharmaceutical manufactures on the expression and the activities of IL-6 and GM-CSF in airway epithelial cells, samples of Hirudo(水蛭), Hirudo toasted with Talcum(水蛭滑石炒) and Hirudo toasted with Ephedrae Herba(水蛭麻黃炒) were tested. Methods : After inducing enhanced messenger RNA(mRNA) expression and secretion of each cytokine by tumor necrosis factor-alpha(10 ng/ml) treatment, cultured human bronchial epithelial cell line BEAS-2B was added to each sample