The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effects of Rhei Rhizoma on c-fos and c-jun Expressions in the Hippocampus of Old BCAO Rats

대황(大黃)이 뇌허혈 유발 노령(老齡) 흰쥐의 해마 c-fos 및 c-jun 발현에 미치는 영향

  • Kim, Ju-Won (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Sung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Shin, Gil-Cho (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Won-Chul (Department of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Paik, Jin-Won (Department of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 김주원 (동국대학교 한의과대학 내과학교실) ;
  • 정승현 (동국대학교 한의과대학 내과학교실) ;
  • 신길조 (동국대학교 한의과대학 내과학교실) ;
  • 이원철 (동국대학교 한의과대학 내과학교실) ;
  • 백진원 (동국대학교 한의과대학 내과학교실)
  • Published : 2004.09.30
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Abstract

Objective : In this study old BCAO rats were observed for effects of 'Dea-Hwang' on brain ischema injury, because risk of stroke increases with age. Method : The brain ischema injury was induced by temporarily closing carotids on both sides in a low blood pressuer state and Dea-Hwang was administered orally to 18 month-old BCAO rats. Results and Conclusions : The ischemically damaged Hippocampus and c-fos and c-jun expression were analyzed by immunohistochemical staining and results are summarized as follows: 1. The c-fos expression after inducing a brain ischema injury in the hippocampus was more inhibited in the dosed group than in the control group. 2. The normalized optical density of c-fos expression was more reduced in the CA1, CA2, and DG areas of the dosed group than in those of the control group. 3. The c-jun expression after inducing brain ischema injury in the hippocampus was more inhibited in the dosed group than in the control group. 4. The normalized optical density of c-jun expression was more reduced in the CAI area of the dosed group than in that of the control group.

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