Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Enantioseparation of Racemic 1,1'Binaphthyl-2,2'diamine by Preparative Liquid Chromatography

  • Ryoo, Jae-Jeong (Dept. of Chemistry, Graduate School, Kyungpook National University) ;
  • Kwon, Woo-Jeong (Dept. of Chemistry, Graduate School, Kyungpook National University) ;
  • Kim, Tae-Hyuk (Dept. of Chemistry, Graduate School, Kyungpook National University) ;
  • Lee, Kwang-Pill (Dept. of Chemistry, Graduate School, Kyungpook National University) ;
  • Choi, Seong-Ho (Dept. of Chemistry, Hannam University)
  • Published : 2004.09.20
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Abstract

The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1'-Binaphthyl-2,2'-diamine(4).

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References

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