Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Tetrahydrocarbazole Derivatives as Potent β3-Adrenoceptor Agonists

  • Ha, Jae-Du (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Kang, Seung-Kyu (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Cheon, Hyae-Gyeong (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Choi, Joong-Kwon (Medicinal Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2004.12.20
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Abstract

A series of 2-(3-chlorophenyl)-2-hydroxyethylamine derivatives containing a tetrahydrocarbazole linker were prepared and evaluated for their ${\beta}_3$-adrenoceptor agonistic activity. Several compounds showed potency comparable to CL-316243.

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References

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