Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Alkoxybenzylcyanoguanidine Analogs as a Novel Class of Inhibitors for Restenosis

  • Lee, Sun-Kyung (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Yi, Kyu-Yang (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Hwang, Sun-Kyung (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Suh, Jee-Hee (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Lee, Byung-Ho (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Yoo, Sung-Eun (Medicinal Science Division, Korea Research Institute of Chemical Technology)
  • Published : 2004.07.20
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Abstract

A novel class of alkoxybenzylcyanoguanidine analogs as the inhibitors of restenosis was discovered, which showed the inhibitory effects on angiotensin II-induced cell proliferation, determined by $[^3H]$thymidine incorporation method. The compound, N'-(4-nitrophenyl)guanidine analog 19, showed 62% inhibition of $[^3H]$thymidine incorporation at 1 ${\mu}M$ concentration. In addition, the compound 19 inhibited intimal thickening dose-dependently after balloon injury, which suggests the therapeutic potential for restenosis.

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References

  1. Orford, J. L.; Selwyn, A. P.; Ganz, P.; Poma, J. J.; Rogers, C. Am. J. Cardiol. 2000, 86(suppl), 6H. https://doi.org/10.1016/S0002-9149(00)01094-8
  2. Lincoff, A. M.; Topol, E. J.; Ellis, S. G. Circulation 1994, 90, 2070. https://doi.org/10.1161/01.CIR.90.4.2070
  3. Bult, H. TiPS 2000, 21, 274.
  4. Pretre, R.; Orford, J. L. JAMA 2001, 285, 992. https://doi.org/10.1001/jama.285.8.992
  5. Faxon, D. P.; Williams, D. O.; Yeh, W.; Mehra, A.; Holubokov, R.; Detre, K. J. Am. Coll. Cardiol. 1999, 33(suppl A), 91A.
  6. Brooks, G.; La Thangue, N. B. DDT 1999, 4, 455. https://doi.org/10.1016/S1359-6446(99)01400-2
  7. Durand, E.; Mallat, Z.; Addad, F.; Vilde, F.; Desnos, M.; Guerot, C.; Tedgui, A.; Lafont, A. J. Am. Coll. Cardiol. 2002, 39, 1680. https://doi.org/10.1016/S0735-1097(02)01831-4
  8. Neumann, F. J.; Ott, I.; Gawaz, M.; Puchner, G.; Schomig, A. J. Am. Coll. Cardiol. 1996, 27, 819. https://doi.org/10.1016/0735-1097(95)00563-3
  9. Kornowsk, R.; Hong, M. K.; Tio, F. O.; Bramwell, O.; Wu, H.; Leon, M. B. J. Am. Coll. Cardiol. 1998, 31, 224. https://doi.org/10.1016/S0735-1097(98)81610-0
  10. Rogers, C.; Edelman, E. R.; Simon, D. I. Proc. Natl. Acad. Sci. USA 1998, 95, 10134. https://doi.org/10.1073/pnas.95.17.10134
  11. Simon, D. I.; Chen, Z.; Seifert, P.; Edelmann, E.; Ballantyne, C. M.; Rogers, C. Circulation 1998, 98, 238.
  12. Nair, S. V.; McEwan, J. R. Int. J. Biochem. & Cell. Biol. 2003, 35, 1399. https://doi.org/10.1016/S1357-2725(03)00135-3
  13. Scott, N. Circulation 1995, 93, 2178.
  14. Yoo, S.-e.; Yi, K. Y.; Lee, S.; Suh, J.; Kim, N.; Lee, B. H.; Seo, H. W.; Kim, S.-O.; Lee, D.-H.; Lim, H.; Shin, H. S. J. Med. Chem. 2001, 44, 4207. https://doi.org/10.1021/jm010183f
  15. Omura, K.; Swern, D. Tetrahedron 1978, 34, 1651. https://doi.org/10.1016/0040-4020(78)80197-5
  16. Atwal, K. S.; Ahmed, S. Z.; O'Reilly, B. C. Tetrahedron Lett. 1989, 30, 7313. https://doi.org/10.1016/S0040-4039(00)70685-X
  17. Bunkenburg, B.; van Amelsvoort, T.; Rogg, H.; Wood, J. M. Hypertension 1992, 20, 746. https://doi.org/10.1161/01.HYP.20.6.746
  18. Pan, S.-L.; Huang, Y.-W.; Guh, J.-H.; Chang, Y.-L.; Peng, C.-Y.; Teng, C. M. Biochem. Pharmacol. 2003, 65, 1897. https://doi.org/10.1016/S0006-2952(03)00161-8
  19. Clowes, A. W.; Schwartz, S. M. Circ. Res. 1985, 56, 139. https://doi.org/10.1161/01.RES.56.1.139
  20. Virone-Oddos, A.; Desangle, V.; Provost, D.; Cazes, M.; Caussade, F.; Cloarec, A. Br. J. Pharmacol. 1997, 120, 488. https://doi.org/10.1038/sj.bjp.0700897