The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
권호 표지

Effect of Youn-Gyo-Pae-Doc-San on the Release of Thymus and Activation-Regulated Chemokine(TARC) in Human Bronchial Epithelial Cell

連翹敗毒散이 사람 기관지 상피세포의 TARC 분비에 미치는 효과

  • 이경엽 (세명대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김희택 (세명대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 남창규 (세명대학교 한의과대학 내과학교실) ;
  • 류주현 (세명대학교 전기공학부)
  • Published : 20031200
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Abstract

Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. The thymus and activation-regulated chemokine (TARC) is a CC chemokine which potentially plays a role via a paracrine mechanism in the development of allergic respiratory diseases. Objectives : The objective of this study is to investigate the effect of Youn-Gyo-Pae-Doc-San on the secretion of TARC of human bronchial epithelial cell Methods : Enzyme-linked immunosorbent assay (ELISA) was performed to detect the secretion of TARC. The cytotoxicity was measured by MTT assay. Results : Youn-Gyo-Pae-Doc-San significantly inhibited the secretion of TARC with a dose -dependant manner. The effective dosage did not have the cytotoxicity on human bronchial epithelial cell. Conclusions : Results of our study show that Youn-Gyo-Pae-Doc-San would play an important role in modulation of TARC in human bronchial epithelial cells.

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