Journal of the Korean Academy of Child and Adolescent Psychiatry
- Volume 14 Issue 1
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- Pages.112-122
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- 2003
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- 2233-9183(eISSN)
STUDY ON THE RELATIONSHIP BETWEEN ONTOGENY OF SEROTONIN SYSTEM AND PSYCHOPATHOLOGY IN CONDUCT DISORDER
행동장애에 있어서 Serotonin계의 개체발생적인 과정과 정신병리와의 상호관계에 관한 연구
- Shin, Sun-Woong (Department of Psychiatry, Division of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital) ;
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Shin, Min-Sup
(Department of Psychiatry, Division of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital) ;
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Hwang, Jun-Won
(Department of Psychiatry, Division of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital) ;
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Kim, Boong-Nyun
(Department of Psychiatry, Division of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital) ;
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Cho, Soo-Churl
(Department of Psychiatry, Division of Child and Adolescent Psychiatry, College of Medicine, Seoul National University Hospital)
- 신성웅 (서울대학교병원 소아 청소년정신과) ;
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신민섭
(서울대학교병원 소아 청소년정신과) ;
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황준원
(서울대학교병원 소아 청소년정신과) ;
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김붕년
(서울대학교병원 소아 청소년정신과) ;
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조수철
(서울대학교병원 소아 청소년정신과)
- Published : 2003.06.30
Abstract
Objectives:Considerable data indicate that diminished serotonergic activity is related to aggressive behavior. In order to understand the biological etiology in conduct disorder, we studied the relationships of plasma serotonin and 5-HIAA levels in conduct disorders to measures of aggression, violation of rules and oppositional defiant behavior. Methods:Subjects were selected from inpatients and outpatients department of the Division of Child and Adolescent Psychiatry of Seoul National University Hospital. 41 conduct disorders(18 childhoodonset type, 23 adolescent-onset type) and 23 normal controls were included in this study. For the assessment of aggression, rule violation and oppositional behavior, parents completed the rating scale for conduct disorder and oppositional behavior based on the DSM-IV diagnostic criteria. Plasma serotonin and 5-HIAA levels were determined by HPLC with electrochemical detection. Results:1) Plasma 5-HT and 5-HIAA levels were not significantly different among childhood-onset conduct disorder, adolescent-onset conduct disorder and normal control subjects. 2) No significant correlations were found between plasma 5-HT levels and aggression or rule violation. 3) Plasma 5-HT levels showed significant positive correlations with oppositional behavior both in childhood-onset conduct disorder and adolescent-onset conduct disorder. 4) Age-related changes were not found in plasma 5-HT and 5-HIAA levles. Conclusion:Our findings do not support the hypothesis that dysregulation of serotonergic function may be associated with aggresson. Instead, our data suggest that serotonergic function is more closely related with oppositional behavior than aggression.
목 적:행동장애의 생물학적인 원인을 규명하고 연령 및 정신병리와의 상호관계를 이해하기 위하여 혈장내의 5-HT와 5-HIAA 농도를 측정하여 대조군과 비교하고, 정신병리, 연령간의 상호관계를 연구하였다. 방 법:1999년 3월부터 2002년 3월 사이 서울대학교병원 소아