생물정신의학 (Korean Journal of Biological Psychiatry)
- 제10권2호
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- Pages.168-176
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- 2003
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
강박장애에서 LORETA 영상을 이용한 P300 국소원의 통계적 분석
The P300 Source Localization in the Patients with Obsessive-Compulsive Disorder using the LORETA Imaging and SPM
- 박성근 (서울대학교 의과대학 정신과학교실) ;
- 최정석 (서울대학교 의과대학 정신과학교실) ;
- 유소영 (서울대학교 의과대학 정신과학교실) ;
- 이보름 (서울대학교 의과대학 서울대학교병원 임상의학연구소) ;
- 강승석 (서울대학교 의과대학 서울대학교병원 임상의학연구소) ;
- 노규식 (서울대학교 의과대학 정신과학교실) ;
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하태현
(서울대학교 의과대학 정신과학교실) ;
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권준수
(서울대학교 의과대학 정신과학교실)
- Park, Sung-Kun (Department of Psychiatry, Seoul National University College of Medicine) ;
- Choi, Jung-Seok (Department of Psychiatry, Seoul National University College of Medicine) ;
- Yu, Soh-Young (Department of Psychiatry, Seoul National University College of Medicine) ;
- Lee, Bo Reom (Clinical Research Institute, Seoul National University Hospital, College of Medicine) ;
- Kang, Seung-Suk (Clinical Research Institute, Seoul National University Hospital, College of Medicine) ;
- Roh, Kyu Sik (Department of Psychiatry, Seoul National University College of Medicine) ;
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Ha, Tae-Hyun
(Department of Psychiatry, Seoul National University College of Medicine) ;
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Kwon, Jun Soo
(Department of Psychiatry, Seoul National University College of Medicine)
- 발행 : 2003.11.30
초록
Objectives:We investigated the characteristics of P300 generators in obsessive-compulsive disorder(OCD) patients by using voxel-based statistical parametric mapping of current density images. Methods:P300 generators, produced by a rare target tone of 1500Hz under a frequent non-target tone of 1,000Hz, were measured in 15 right-handed OCD patients and 15 controls. Low Resolution Electromagnetic Tomography(LORETA), using a realistic head model of the boundary element method based on individual MRI, was applied to the 128-channel EEG. Statistical parametric mapping(SPM) was applied for the statistical analysis. Results:We found that both groups had the mean current density of P300 in the parietal, temporal and prefrontal lobe. There was a trend for decreased current density in the prefrontal area in OCD patients. The statistical comparison showed current density increase in the supraparietal area, a statistically significant longer P300 latency and a trend for reduced P300 amplitude in OCD patients. Conclusion:It suggests that P300 source of both groups exists in multiple brain regions at the same time. And both groups had no statistically significant differences in the current density of P300 except for increased current density in the supraparietal area in OCD patients. But, considering the statistically significant longer P300 latency, a trend for reduced P300 amplitude and relative mean current density reduction in the prefrontal area in OCD patients, this study suggests that the frontal lobe may have a reduced normal inhibitory process in OCD patients.