Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Association of a Polymorphism in the Promoter Region of Apo-1/Fas Gene with Bipolar Disorder

양극성 장애 환자에서 Apo-1/Fas Promoter 유전자 다형성

  • Kim, Kyu Hyun (Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
  • Son, So-Jeong (Seoul National Hospital) ;
  • Lee, Hee Jae (Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
  • Kim, Jong Woo (Kohwang Medical Research Institute, College of Medicine, Kyunghee University) ;
  • Chung, Joo-Ho (Kohwang Medical Research Institute, College of Medicine, Kyunghee University)
  • 김규현 (경희대학교 의과대학 고황의학연구소) ;
  • 손소정 (국립서울병원) ;
  • 이희제 (경희대학교 의과대학 고황의학연구소) ;
  • 김종우 (경희대학교 의과대학 고황의학연구소) ;
  • 정주호 (경희대학교 의과대학 고황의학연구소)
  • Published : 2003.11.30
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Abstract

Objective:Recently, many experimental evidences have been reported that psychiatric diseases are closely related with neurodevelopmental abnormalities and this can be properly explained by apoptosis. It is known that Apo-1/Fas is one of the genes in charge of apoptosis related with neurodevelopmental abnormalities. In this study, the association between bipolar disorder and functional polymorphism in Apo-1/Fas promoter gene has been investigated. Method:For 81 bipolar disorder patients and 217 healthy control subjects, MvaI restriction fragment length polymorphism(RFLP) of Apo-1/Fas promoter gene was analyzed after polymerase chain reaction(PCR) amplification. Result:There was a statistical significant difference in genotypic distribution(${\chi}^2$=16.656, df=2, p=0.0002) and allelic frequencies(${\chi}^2$=14.225, df=1, p=0.0002) between bipolar disorder patients and healthy control subjects. Conclusion:Our results suggest an association between functional polymorphism in Apo-1/Fas promoter gene and bipolar disorder and provide the important genetic information related with the pathogenesis of the disease. Further studies employing larger samples are required to clarify the present results.

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