Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 10 Issue 2
- /
- Pages.107-115
- /
- 2003
- /
- 1225-8709(pISSN)
- /
- 2005-7571(eISSN)
Antipsychotics and Abnormality in Glucose Regulation
항정신병 약물과 혈당조절이상
- Hwang, Jae-Sung (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
- Kim, Hyun (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
-
Kwon, Young-Joon
(Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital)
;
-
Jung, Hee-Yeon
(Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital)
- 황재승 (순천향대학교 의과대학 천안병원 정신과학교실) ;
- 김현 (순천향대학교 의과대학 천안병원 정신과학교실) ;
-
권영준
(순천향대학교 의과대학 천안병원 정신과학교실)
;
-
정희연
(순천향대학교 의과대학 천안병원 정신과학교실)
- Published : 2003.11.30
Abstract
Objective:The purpose of this study was to know about the mechanism of pathogenesis of type 2 diabetes mellitus by using of blood glucose, glucoregulatory factor, insulin resistance in schizophrenic patients receiving antipsychotics. Method:Modified oral glucose tolerance tests were performed in 20 schizophrenic patients receiving haloperidol, risperidone and olanzapine. Insulin, glucagon, C-peptide and cortisol were measured in 0, 15, 45, 75 minutes after glucose loading, and insulin resistance was calculated by HOMA(homeostasis model assessment) method. Result:Olanzapine-treated patients had significant glucose elevation 45 minutes after glucose challenge. Also modest increases in HOMA IR values were detected in patients treated with olanzapine. Conclusion:Olanzapine treatment of non-diabetic patients with schizophrenia can be associated with type 2 diabetes mellitus through the elevation of glucose and insulin resistance. Elevated insulin resistance may be a causative mechanism of type 2 diabetes mellitus in patients receiving olanzapine.