Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of the Bleomycin-Induced Bronchiolitis Obliterans Organizing Pneumonia

Bleomycin 투여 후 발생한 폐쇄세기관지기질화폐렴

  • Hahn, Chang Hoon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Moon, Jin Wook (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Jae Hyun (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Choi, Byoung Wook (Department of Diagnostic Radiology, Yonsei University College of Medicine) ;
  • Shin, Dong Whan (Department of Pathology, Yonsei University College of Medicine) ;
  • Kim, Se Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Chang, Joon (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Sung Kyu (Department of Internal Medicine, Yonsei University College of Medicine) ;
  • Kim, Young Sam (Department of Internal Medicine, Yonsei University College of Medicine)
  • 한창훈 (연세대학교 의과대학 내과학교실) ;
  • 문진욱 (연세대학교 의과대학 내과학교실) ;
  • 장제현 (연세대학교 의과대학 내과학교실) ;
  • 최병욱 (연세대학교 의과대학 진단방사선과학교실) ;
  • 신동환 (연세대학교 의과대학 병리학교실) ;
  • 김세규 (연세대학교 의과대학 내과학교실) ;
  • 장준 (연세대학교 의과대학 내과학교실) ;
  • 김성규 (연세대학교 의과대학 내과학교실) ;
  • 김영삼 (연세대학교 의과대학 내과학교실)
  • Published : 2003.09.30
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Abstract

A 34-year-old man was admitted to our hospital due to fever and cough. He received the combination anti-cancer chemotherapy for testicular tumor, including bleomycin. The chest X-ray showed consolidation and ground glass opacity on the right upper lobe and subpleural areas of other lobes. This condition was initially misdiagnosed as a pneuomonia, but consolidation did not disappear after antibiotics treatment. We performed transbronchial lung biopsy and bleomycin induced pulmonary toxicity was confirmed. The bleomycin induced lung injury is the most common chemotherapeutically induced pulmonary disease. Bleomycin induced Bronchiolitis Obliterans Organizing Pneumonia(BOOP) is less common than interstitial pneumonitis and responds well to corticosteroid treatment.

저자들은 폐전이가 동반된 고환암 환자에서 bleomycin을 포함한 항암화학요법제 투여 후 발열과 기침을 호소하는 환자에서 발생한 약물 유발성 폐독성으로 인한 폐쇄세기관지기질화폐렴 양상의 폐손상을 문헌 고찰과 함께 보고하는 바이다.

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