대한두경부종양학회지 (Korean Journal of Head & Neck Oncology)

  • 제19권1호
  • /
  • Pages.21-24
  • /
  • 2003
  • /
  • 1229-5183(pISSN)
  • /
  • 2586-2553(eISSN)
대한두경부종양학회 (The Korean Society for Head and Neck Oncology)
권호 표지

ALA 및 ALA-Methylester의 투여에 따른 종양조직 및 정상조직에의 분포양상에 대한 연구

Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester

  • 정필상 (단국대학교 의과대학 이비인후과학교실) ;
  • 정상운 (단국대학교 의과대학 의학레이저연구센터) ;
  • 안진철 (단국대학교 의과대학 의학레이저연구센터) ;
  • 이상준 (단국대학교 의과대학 이비인후과학교실) ;
  • 윤준식 (단국대학교 의과대학 이비인후과학교실)
  • Chung Phil-Sang (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine) ;
  • Jung Sang-Oun (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine) ;
  • Ahn Jin-Chul (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine) ;
  • Lee Sang-Joon (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine) ;
  • Yoon Jun-Sik (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine)
  • 발행 : 2003.05.01
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초록

Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.

키워드

참고문헌

  1. Ades IZ : Heme production in animal tissue : the regulation of biosynthesis of $\delta$-aminolevulininate synthase. Int J Biochem. 1992 ; 14 : 275-299
  2. van der Veen N, Hebeda KM, de Bruijn HS, Star WM : Photodynamic effectiveness and vasoconstriction in hairless mouse skin after topical 5-aminolevulinic acid and single- or two-fold illimination. Photochem Photobiol. 1999 ; 70 : 921-929 https://doi.org/10.1111/j.1751-1097.1999.tb08303.x
  3. Peng Q, Berg K, Moan J, Kongshaug M, Nesland JM : 5-Aminolevulinic acid-based photodynamic therapy : principles and experimental research. Photochem Photobiol. 1997 ; 65 : 235-251 https://doi.org/10.1111/j.1751-1097.1997.tb08549.x
  4. Sharman WM, Allen CM, van Lier JE : Photodynamic therapeutics : basic principles and clinical applications. DDT. 1999 ; 4 : 507-517 https://doi.org/10.1016/S1359-6446(99)01412-9
  5. Zheng W, Olivo M, Sivanandan R, et al : Endoscopy imaging of 5-ALA-induced PPIX fluorescence for detecting early neoplasm in oral cavity. SPIE. 2001 ; 4597 : 128-132 https://doi.org/10.1117/12.446648
  6. Yee KKL, Soo KC, Bay BH, Olivo M : A comparison of protoporphyrin IX and protoporphyrin IX dimethyl ester. as a photosensitizer in poorly diffrentiated human nasopharyngeal carcinoma cells. Photochem Photobiol. 2002 ; 76 : 678-682. https://doi.org/10.1562/0031-8655(2002)076<0678:ACOPIA>2.0.CO;2
  7. Finlay JC, Conover DL, Hull EL, Foster TH : Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo. Photochem Photobiol. 2001 ; 73 : 54-63 https://doi.org/10.1562/0031-8655(2001)073<0054:PBAPIS>2.0.CO;2
  8. Brunner H, Hausmann F, Krieg RC, et al : The effects of 5-aminolevulinic acid esters on protoporphyrin IX production in human adenocarcinoma cell lines. Photochem Photobiol. 2001 ; 74 : 721-725 https://doi.org/10.1562/0031-8655(2001)074<0721:TEOAAE>2.0.CO;2
  9. Gederaas OA, Holroyd A, Brown SB, et al : 5-aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochem Photobiol. 2001 ; 73 : 164-169 https://doi.org/10.1562/0031-8655(2001)073<0164:AAMETO>2.0.CO;2