Korean Journal of Head & Neck Oncology (대한두경부종양학회지)

The Korean Society for Head and Neck Oncology (대한두경부종양학회)
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Distribution Patterns in the Tumor Tissue and Normal Tissue according to the Administration Methods of ALA and ALA-Methylester

ALA 및 ALA-Methylester의 투여에 따른 종양조직 및 정상조직에의 분포양상에 대한 연구

  • Chung Phil-Sang (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine) ;
  • Jung Sang-Oun (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine) ;
  • Ahn Jin-Chul (Depatemtne of Medical Laser Reserch Center, Dankook University College of Medicine) ;
  • Lee Sang-Joon (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine) ;
  • Yoon Jun-Sik (Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine)
  • 정필상 (단국대학교 의과대학 이비인후과학교실) ;
  • 정상운 (단국대학교 의과대학 의학레이저연구센터) ;
  • 안진철 (단국대학교 의과대학 의학레이저연구센터) ;
  • 이상준 (단국대학교 의과대학 이비인후과학교실) ;
  • 윤준식 (단국대학교 의과대학 이비인후과학교실)
  • Published : 2003.05.01
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Abstract

Objectives: In this report, we confirmed the distributed pattern of ALA and ALA-methylester in normal and tumor-bearing region. Materials and Methods: ALA and ALA-methylester were administered to nude mouse by intratumoral, subcutaneous and intravenous injection. After injection, the fluorescence in normal and tumor region was measured by LESA (laser electronic spectrum analyzer). Results: The tumor-specificity of ALA and ALA-methylester was shown in the case of intratumoral injection. In all case, the fluorescence caused by ALA and ALA-methylester was maximally increased in 2 hours after injection. Then while the fluorescence level was rapidly decreased to control level in normal region, it was still remained in tumor region. Conclusion: According to this result, The intratumoral injection was more efficient administration method for PDT/PDD than subcutaneous and intravenous injection.

Keywords

References

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